ADMINISTRATION OF G-CSF AND CHEMOTHERAPY IN PATIENTS WITH LYMPHOMA AND MYELOMA OPTIMIZED SUCCESSFUL MOBILIZATION OF HEMATOPOETIC PROGENITOR CELLS FOR AUTOLOGOUS BLOOD STEM CELL TRANSPLANTATION

Journal
Haematologica, the hematology journal, Abstract book, 2007; 545
Date Issued
2007
Author(s)
Abstract
Introduction. Hematopoetic stem cell mobilization and collection have
been optimized in numerous clinical trials, but significant proportion of
patients mobilize an insufficient number of hematopoetic stem cell,
resulting in an inadequate graft. Classical strategies for peripheral blood
stem cell mobilization include administration of growth factors, mainly
G-CSF alone or in combination with marrow suppressive chemotherapy.
The administration of a combination of chemotherapy and
cytokines G-CSF is associated with a significantly increased efficacy of
stem cell mobilization compared with either modality alone. Method.
The aim of this study was to evaluate the efficacy of G-CSF preceded
by chemotherapy (cyclophosphamide 4g/m sq for 1 dose) for hematopoetic
progenitor cell mobilization for lymphoma and myeloma patients.
We started G-CSF as a fixed dose 480MU SQ every day as soon as the
leukocyte counts began to rise after chemotherapy induced myelosupression.
Leukapheresis was commenced at the time when leukocyte count
rose up to 1000/uL, and repeated for 2-4 consecutive days until target
number of CD34+ cell, at least 2×106/kg was collected. Results. 39 (male
to female, 21:18, age range 21-65, lymphoma 25, myeloma 14) underwent
a total of 86 courses of leukapheresis for hematopoetic progenitor
cell collection prior to autologous transplantation from April 2002
through October 2006. The target amount of marrow was harvest in all
patients. All the patients achieved good engraftment after autologous
transplantation. The mean days required for WBC count to be over
1,000/uL was 8-16 days. Patient’s age, sex, underlying malignancy, exposure
to chemotherapy before mobilization did not show any statistically
significant correlation. Conclusion. We can conclude that chemotherapy
followed by G-CSF administration is an effective way for mobilization
of hematopoetic progenitor cell and verified itself as a good mobilization
method.
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ADMINISTRATION OF G-CSF AND CHEMOTHERAPY IN PATIENTS WITH LYMPHOMA AND MYELOMA OPTIMIZED SUCCESSFUL MOBILIZATION OF HEMATOPOETIC PROGENITOR CELLS FOR AUTOLOGOUS BLOOD STEM CELL TRANSPLA.pdf

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