Ectopic Prostatic Tissue in Uterine Cervix: A Case Report
Journal
American Journal of Surgery and Clinical Case Reports
Date Issued
2022-04
Author(s)
Angelovska, Tamara
Tanturovski, Dragan
Trajkovikj, Sofija
Abstract
Speaking about prostate in the context of a female patient would
sound rather odd to the vast majority of interlocutors. We describe
a case of ectopic prostatic tissue in the uterine cervix in a 30 years
old patient. The microscopic analysis of the cervical cone biopsy
showed H-SIL in the lower-left quadrant, diffuse foci of L-SIL,
as well as a focus of low-grade cervical glandular intraepithelial
neoplasia in the lower-left quadrant. Tubulo-alveolar glands were
incorporated deeply in the cervical stroma were identified in the
lower right quadrant, lined with two-layered,cuboidal to columnar,
secretory epithelium, resting on a basal cell layer. The immunohis-
tochemical analysis showed strong and diffuse PSA positivity in
the superficial secretory cells, while the basal cells were CKHMW
positive, as well as a partial positivity of Smooth muscle actin.
Diagnosis of H-SIL accompanied by LCGIN and aberrant prostat-
ic glands in the cervical stroma was made. In almost all reported
cases, ectopic prostatic tissue in the female genital tract is a benign
condition, although a further follow-up of the patients is required.
Possible theories of histogenesis include a developmental anoma-
ly, metaplasia of pre-existing endocervical glands, and derivation
from mesonephric remnants. It is important that pathologists be
aware of this condition and to take it into account in the differential
diagnosis.
sound rather odd to the vast majority of interlocutors. We describe
a case of ectopic prostatic tissue in the uterine cervix in a 30 years
old patient. The microscopic analysis of the cervical cone biopsy
showed H-SIL in the lower-left quadrant, diffuse foci of L-SIL,
as well as a focus of low-grade cervical glandular intraepithelial
neoplasia in the lower-left quadrant. Tubulo-alveolar glands were
incorporated deeply in the cervical stroma were identified in the
lower right quadrant, lined with two-layered,cuboidal to columnar,
secretory epithelium, resting on a basal cell layer. The immunohis-
tochemical analysis showed strong and diffuse PSA positivity in
the superficial secretory cells, while the basal cells were CKHMW
positive, as well as a partial positivity of Smooth muscle actin.
Diagnosis of H-SIL accompanied by LCGIN and aberrant prostat-
ic glands in the cervical stroma was made. In almost all reported
cases, ectopic prostatic tissue in the female genital tract is a benign
condition, although a further follow-up of the patients is required.
Possible theories of histogenesis include a developmental anoma-
ly, metaplasia of pre-existing endocervical glands, and derivation
from mesonephric remnants. It is important that pathologists be
aware of this condition and to take it into account in the differential
diagnosis.
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