One-year retrospective study of hospitalized patients on parenteral bisphosphonate therapy at Univ.Kl. for Endocrinology, Diabetes and Metabolic Disorders, Skopje, Republic of Northern Macedonia.

Abstract

ONE-YEAR RETROSPECTIVE STUDY OF HOSPITALISED PATIENTS ON PARENTERAL THERAPY WITH BISPHOSPHONATES AT THE UNIVERSITY CLINIC OF ENDOCRINOLOGY IN SKOPJE, MACEDONIA A. Mucha, V. Limani, S. Markovikj University Clinic of Endocrinology, Diabetes and Metabolic Diseases, Skopje, Macedonia Objective: To evaluate hospitalised patients with diagnosed osteoporosis for a 1-y period at the university clinic of endocrinology, diabetes and metabolic diseases in Skopje, Macedonia. Methods: National electronic database was searched during the period January-December 2018. The retrospective study was performed including all hospitalised patients on parenteral form of bisphosphonates addressing gender, age, duration of disease, risk factors as well as other comorbidities. Results: A total of 59 patients were analysed. 54 were females (91,5%) and only 5 were males (8,5%). The average age of hospitalised patients was 65.13 y; only 2 of analysed patients were below 40 y of age (females, 34 years old and 25 y respectively). 6 of patients were having familiar anamnesis for osteoporosis (10.15%). Study shows that 17 of patients are smokers (28.8%). All 59 patients have other comorbidities, mostly with hypertension, gastrointestinal problems and diabetes. 31 patients who were hospitalised had bone fractures (52.54%). The cause for osteoporosis in 43 of 59 patients (72,88%) was early menopauses. Other cause was primary hyperparathyroidism and use of corticosteroids. Conclusions: Most of the patients in our country (around 74%) who are on parenteral therapy with bisphosphonates are treated at university clinic of endocrinology, diabetes and metabolic diseases. This retrospective study shows that more than 90% of patients are females, every second patient had a bone fracture and almost every third patient is a smoker. In every 10 patients, 7 of them had an early menopause as a main cause for osteoporosis.