Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/26094
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gjorgjievska, Kalina | en_US |
dc.contributor.author | Petrushevska, Marija | en_US |
dc.contributor.author | Zendelovska, Dragica | en_US |
dc.contributor.author | Atanasovska, Emilija | en_US |
dc.contributor.author | Spasovska, Katerina | en_US |
dc.contributor.author | Stevanovikj, Milena | en_US |
dc.contributor.author | Grozdanovski, Krsto | en_US |
dc.date.accessioned | 2023-03-14T11:06:23Z | - |
dc.date.available | 2023-03-14T11:06:23Z | - |
dc.date.issued | 2022-07-13 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/26094 | - |
dc.description.abstract | Background/aim: Hematological parameters are the starting point in COVID-19 severity classification. The aim of this study was to analyze oxidative stress in hospitalized COVID-19 patients and to determine its association with D-dimer, neutrophil to lymphocyte ratio (NLR), and platelets to lymphocyte ratio (PLR) as markers for disease progression. Materials and methods: 52 patients with moderate and severe forms of COVID-19 were enrolled. A hematological and coagulation profile was performed for each patient. PAT (total antioxidant power, iron-reducing) and d-ROMs (plasma peroxides) were determined in serum at admission and 7 days after hospitalization. Results: The severe group presented parameters that indicated a poor prognosis. Patients that recovered had a significant reduction in d-ROM (t-test, p<0.01) and improvement in oxidative stress index (t-test, p<0.05). Patients that died had significantly decreased PAT (p<0.01) resulting in an increase in oxidative stress. Except for d-ROM vs PLR in both groups and d-ROM vs D-dimer in the severe group, a good correlation between oxidative stress parameters and D-dimer, PLR, and NLR was demonstrated (p<0.01). Conclusion: Our results show that oxidative stress markers can be used as a tool for disease progression in COVID-19. This analysis is easily accessible and affordable in addition to conventional hematological parameters performed for severity classification. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Macedonian Academy of Sciences and Arts/Sciendo | en_US |
dc.relation.ispartof | Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) | en_US |
dc.title | Hematological Findings and Alteration of Oxidative Stress Markers in Hospitalized Patients with SARS-COV-2 | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.2478/prilozi-2022-0029 | - |
dc.identifier.url | https://www.sciendo.com/pdf/10.2478/prilozi-2022-0029 | - |
dc.identifier.volume | 43 | - |
dc.identifier.issue | 2 | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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