Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/24764
Title: | The Role of the Beta-Amyloid Precursor Protein in the Diagnosis of Diffuse Axonal Injury | Authors: | Davcheva, N Dimitrova, M Kadiysky, D Grozeva, M Basheska, N |
Keywords: | diffuse axonal injury β-amyloid precursor protein immunohistochemistry forensic medicine. |
Issue Date: | 2015 | Publisher: | Bulgarian Academy of Sciences, Prof. Marin Drinov Publishing House | Journal: | Acta morphologica et anthropologica | Abstract: | Diffuse axonal injury (DAI) is a distinct clinical-pathological entity in the closed head injuries, where very often, the macroscopic lesion of the brain tissue cannot be found. Hence, in those cases the microscopic examination is of a huge importance. Using the conventional staining techniques the axonal injuries can be perceived only if there has been a survival of up to 24 hours (hematoxylin and eosin staining), or 12 to 18 hours (silver impregnation methods). With the introduction of immunohistochemistry using antibodies against β-Amyloid Precursor Protein (β-APP), this period has been shortened to 3 hours, even less. In the present paper, a review on the role of β-APP immunohistochemistry in the diagnosis of DAI is presented. This review shows that β-APP immunohistochemistry can be a very powerful tool in diagnosing the axonal injuries, what is of a special significance for the forensic medicine practice. | URI: | http://hdl.handle.net/20.500.12188/24764 | ISSN: | 1311-8773 |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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154-158 Davceva.pdf | 528.29 kB | Adobe PDF | View/Open |
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