Superficial leiomyomas of the gastrointestinal tract with interstitial cells of Cajal
Journal
International journal of clinical and experimental pathology
Date Issued
2015
Author(s)
Qerimi, Adelina
Stojkova, Elena
Abstract
Objective: Some authors suggest common origin of gastrointestinal stromal tumors from stem cells, which
may show diverse differentiation. There are reports in which cells morphologically identical to the interstitial cells
of Cajal are found in deep leiomyomas. The aim of this study was to demonstrate CD117 positive cells in superficial
gastrointestinal (GI) leiomyomas and to find other cells that would suggest diverse differentiation in histologically
typical leiomyoma. Materials and methods: We analyzed 8 cases of superficial leiomyomas and one deep leiomyo-
ma, received in our institutions as endoscopically or surgically obtained material. The tumor sections were immuno-
histochemicaly stained with CD117, CD34, NF, S100, αSMA, desmin, caldesmon and mast cell antigen. Results: All
leiomyomas showed diffuse positivity for αSMA, caldesmon and desmin. All of them had CD117 and CD34 positive
cells morphologically identical to the interstitial cells of Cajal between smooth muscle fibers, 5 had S-100 and NF
positive cells and 2 showed positivity for GFAP. The cells were found in different quantity; they were usually diffusely
scattered through the tumors without predilection site, forming small groups in some areas. Conclusion: CD177,
CD34, S-100 and NF positive cells are present in superficial leiomyomas and they may suggest common origin of
GI stromal tumors.
may show diverse differentiation. There are reports in which cells morphologically identical to the interstitial cells
of Cajal are found in deep leiomyomas. The aim of this study was to demonstrate CD117 positive cells in superficial
gastrointestinal (GI) leiomyomas and to find other cells that would suggest diverse differentiation in histologically
typical leiomyoma. Materials and methods: We analyzed 8 cases of superficial leiomyomas and one deep leiomyo-
ma, received in our institutions as endoscopically or surgically obtained material. The tumor sections were immuno-
histochemicaly stained with CD117, CD34, NF, S100, αSMA, desmin, caldesmon and mast cell antigen. Results: All
leiomyomas showed diffuse positivity for αSMA, caldesmon and desmin. All of them had CD117 and CD34 positive
cells morphologically identical to the interstitial cells of Cajal between smooth muscle fibers, 5 had S-100 and NF
positive cells and 2 showed positivity for GFAP. The cells were found in different quantity; they were usually diffusely
scattered through the tumors without predilection site, forming small groups in some areas. Conclusion: CD177,
CD34, S-100 and NF positive cells are present in superficial leiomyomas and they may suggest common origin of
GI stromal tumors.
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