Tertiary Lymphoid Structures in Colorectal Cancers and Their Prognostic Value

Journal
Open access Macedonian journal of medical sciences
Date Issued
2018-10-25
Author(s)
Ognjenovic, Ljubomir
Hadzi-Manchev, Dragan
Volcevski, Goce
Abstract
Tumor-infiltrating lymphocytes (TIL) in tumour stroma are considered to be involved in the elimination of malignant cells and prevention of metastasis formation. TIL consist of T lymphocytes including cytotoxic lymphocytes that are a constituent part of the effector mechanism of anti-tumour immunity and B lymphocytes that can form tertiary lymphoid structures (TLS). TLS has been described in several solid tumours and colorectal carcinoma (CRC), and the influence on the local and systemic anti-cancer response.
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