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Наслов: CD150-dependent hematopoietic stem cells sensing of <i>Brucella</i> instructs myeloid commitment
Authors: Lisiena, Hysenaj
Bérengère, De Laval
Vilma, Arce-Gorvel
Mile, Bosilkovski 
Gabriela, Gonzalez
Guillaume, Debroas
Michael, Sieweke
Sandrine, Sarrazin
Jean-Pierre, Gorvel
Issue Date: 1-апр-2021
Publisher: Cold Spring Harbor Laboratory
Journal: BioXriv the preprint server for biology
Abstract: So far, hematopoietic stem cells (HSC) are considered the source of mature immune cells, the latter being the only ones capable of mounting an immune response. Recent evidence shows HSC can also directly sense cytokines released upon infection/inflammation and pathogen-associated molecular pattern interaction, while keeping a long-term memory of previous encountered signals. Direct sensing of danger signals by HSC induces early myeloid commitment, increases myeloid effector cell numbers and contributes to an efficient immune response. Here, using specific genetic tools on both host and pathogen sides, we show that HSC can directly sense B. abortus pathogenic bacteria within the bone marrow via the interaction of the cell surface protein CD150 with the bacterial outer membrane protein Omp25, inducing efficient functional commitment of HSC to the myeloid lineage. This is the first demonstration of a direct recognition of a live pathogen by HSC via CD150, which attests of a very early contribution of HSC to immune response.</jats:p><jats:sec><jats:title>SUMMARY</jats:title><jats:p>This work provides first evidence HSC directly sense Brucella abortus via the bacterial outer membrane protein Omp25 and the HSC surface receptor CD150, leading to functional commitment of HSC to myeloid lineage and very early initiation of immune response.</jats:p></jats:sec>
URI: http://hdl.handle.net/20.500.12188/23686
DOI: 10.1101/2021.03.31.437872
Appears in Collections:Faculty of Medicine: Journal Articles

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