Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/23494
DC Field | Value | Language |
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dc.contributor.author | Trajkova, Sanja | en_US |
dc.contributor.author | Chevrevska, Lidija | en_US |
dc.contributor.author | Pavkovic, Marica | en_US |
dc.contributor.author | Panovska Stavridis, Irina | en_US |
dc.contributor.author | Dukovski, Dushko | en_US |
dc.contributor.author | Popova-Simjanovska Marija | en_US |
dc.contributor.author | Chadievski, Lazar | en_US |
dc.contributor.author | Stojanovikj, Aleksandar | en_US |
dc.date.accessioned | 2022-10-17T08:36:31Z | - |
dc.date.available | 2022-10-17T08:36:31Z | - |
dc.date.issued | 2013-05-10 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/23494 | - |
dc.description.abstract | Chronic myelogenous leukemia (CML) is characterized by the presence of a Bcr-Abl fusion protein with deregulated tyrosine kinase activity that is required for maintaining the malignant phenotype. Imatinib as a selective inhibitor of Bcr-Abl induces complete cytogenetic remission in the majority of patients with CML in chronic phase. Targeted therapy of CML with imatinib favors the manifestation of Ph-(negative) clone disorders in some patients. Facts indicate that patients on imatinib should be followed with conventional cytogenetics, even after induction of complete remission. We report a case of a patient with CML, in chronic phase treated with imatinib which induces the most common abnormality trisomy 8. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Radiance Research Academy | en_US |
dc.relation.ispartof | International Journal of Current Research and Review | en_US |
dc.subject | Chronic myeloic leukemia | en_US |
dc.subject | Imatinib | en_US |
dc.subject | Philadelphia chromosome | en_US |
dc.subject | clone evlotion | en_US |
dc.title | CHROMOSOMAL ABNORMALITIES IN PHILADELPHIA CHROMOSOME- NEGATIVE CELLS IN PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA TREATED WITH FIRST GENERATION TYROSINE KINASE INHIBITOR- SINGLE CENTER EXPERIENCE | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 05 | - |
dc.identifier.issue | 10 | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
Files in This Item:
File | Description | Size | Format | |
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CML Sanja.pdf | 319.91 kB | Adobe PDF | View/Open |
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