FLOW CYTOMETRY DIAGNOSIS OF (CD4+/CD8+) T CELL LYMPHOBLASTIC LEUKEMIA ASSOCIATED WITH NORMAL KARYOTYPE - CASE REPORT
Journal
International Journal of Current Research and Review
Date Issued
2013-04
Author(s)
Ivanovski, Martin
Dukovski, Dushko
Simjanovska-Popova, Marija
Abstract
Adult T-cell leukemia/lymphoma (ATLL) is a peripheral T-cell neoplasm caused by human T-cell
lymphotropic virus type I (HTLV-I). The neoplastic cells are highly pleomorphic and are usually
CD4+ and CD8- phenotypically, but some rare cases have unusual immmunophenotype presented by
co-expression of CD4/CD8 double positive cells. We present a rare case of a patient with T cell
lymphoblastic leukemia associated with double-positive (CD4+/CD8+) blast cells. The diagnose was
accessed with multiparameter immunophenotyping by flow cytometry analyses of bone marrow, and
for the first time in our country, we confirmed isolated relapse of double-positive (CD4+/CD8+) T
cell lymphoblastic leukemia in CNS
lymphotropic virus type I (HTLV-I). The neoplastic cells are highly pleomorphic and are usually
CD4+ and CD8- phenotypically, but some rare cases have unusual immmunophenotype presented by
co-expression of CD4/CD8 double positive cells. We present a rare case of a patient with T cell
lymphoblastic leukemia associated with double-positive (CD4+/CD8+) blast cells. The diagnose was
accessed with multiparameter immunophenotyping by flow cytometry analyses of bone marrow, and
for the first time in our country, we confirmed isolated relapse of double-positive (CD4+/CD8+) T
cell lymphoblastic leukemia in CNS
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