Analysis of Prognostic Factors As Predictors of Treatment Free Survival in Patients with Chronic Lymphocytic Leukemia-Single Centre Experience
Journal
IOSR Journal of Dental and Medical Sciences (IOSR-JDMS)
Date Issued
2021-08
Author(s)
Krstevska-Balkanov, Svetlana
Popova Labachevska, Marija
Stojanovska, Simona
DOI
10.9790/0853-2008133243
Abstract
Introduction: Chronic lymphocytic leukemia (CLL) is a heterogeneous clonal lymphoproliferative disease
originating from activated B lymphocytes that have experienced antigen. The clinical course is very
heterogeneous. Some patients never look for treatment, as opposed to others who live and die with an
aggressive illness. This clinical heterogeneity is likely a reflection of molecular and cellular heterogeneity, on
the basis of which patients with CLL can be divided into subgroups with different clinical-biological
characteristics.
Aim of the study: Evaluation of prognostic factors in terms of treatment free survival, prognosis and adequate
therapeutic approach in patients with CLL.
Material and methods: The study is set as retrospective, it includes 300 patients with CLL diagnosed and
treated at the University Clinic of Hematology in the period of 10 years (January 2009 - January 2019). The
study was performed at the University Clinic for Hematology, Medical Faculty, Ss. Cyril and Methodius
University, Skopje, Republic of North Macedonia. We evaluate several prognostic factors in terms of treatment
free survival. All results were processed with the statistical program SPSS18 software program.
Results: The multivariate Cox Proportional model of Treatment free survival of CLL patients confirmed ECOG,
Rai Stage, and spleen size that influence on treatment free survival..
Concusion: In our study, multivariate analysis of treatment free survival and overall survival showed ECOG
performance status 0,1 and 2 as a factor influencing both overall survival and treatment free survival
originating from activated B lymphocytes that have experienced antigen. The clinical course is very
heterogeneous. Some patients never look for treatment, as opposed to others who live and die with an
aggressive illness. This clinical heterogeneity is likely a reflection of molecular and cellular heterogeneity, on
the basis of which patients with CLL can be divided into subgroups with different clinical-biological
characteristics.
Aim of the study: Evaluation of prognostic factors in terms of treatment free survival, prognosis and adequate
therapeutic approach in patients with CLL.
Material and methods: The study is set as retrospective, it includes 300 patients with CLL diagnosed and
treated at the University Clinic of Hematology in the period of 10 years (January 2009 - January 2019). The
study was performed at the University Clinic for Hematology, Medical Faculty, Ss. Cyril and Methodius
University, Skopje, Republic of North Macedonia. We evaluate several prognostic factors in terms of treatment
free survival. All results were processed with the statistical program SPSS18 software program.
Results: The multivariate Cox Proportional model of Treatment free survival of CLL patients confirmed ECOG,
Rai Stage, and spleen size that influence on treatment free survival..
Concusion: In our study, multivariate analysis of treatment free survival and overall survival showed ECOG
performance status 0,1 and 2 as a factor influencing both overall survival and treatment free survival
File(s)![Thumbnail Image]()
Loading...
Name
prognostic factors cll.pdf
Size
579.29 KB
Format
Adobe PDF
Checksum
(MD5):0f9f3936a154c637383161dd9df05962