VACCINE-INDUCTED THROMBOTIC THROMBOCYTOPENIA AND COVID-19 VACCINES: CASE SERIES
Journal
Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)
Date Issued
2022-01
Author(s)
Lazarova Trajkovska E
Grueva Nastevska E
Gjorgjievski A
Abstract
Vaccine-induced thrombotic thrombocytopenia (VITT) is a condition similar to heparin-induced throm-
bocytopenia (HIT), but it is associated with prior administration of COVID-19 vaccines without prior
exposure to heparin. The incidence of VITT is not certain, but it appears to be extremely rare. Reports of
unusual and severe thrombotic events, including cerebral and splanchnic venous thrombosis and other
autoimmune adverse reactions, such as immune thrombocytopenia or thrombotic microangiopathies in
connection with some of the SARS-CoV-2 vaccines, have caused a great deal of concern within the pop-
ulation and the medical community. We would like to present 4 clinical cases of VITT, hospitalized and
treated in intensive care unit (ICU) of University clinic of cardiology in Skopje.
bocytopenia (HIT), but it is associated with prior administration of COVID-19 vaccines without prior
exposure to heparin. The incidence of VITT is not certain, but it appears to be extremely rare. Reports of
unusual and severe thrombotic events, including cerebral and splanchnic venous thrombosis and other
autoimmune adverse reactions, such as immune thrombocytopenia or thrombotic microangiopathies in
connection with some of the SARS-CoV-2 vaccines, have caused a great deal of concern within the pop-
ulation and the medical community. We would like to present 4 clinical cases of VITT, hospitalized and
treated in intensive care unit (ICU) of University clinic of cardiology in Skopje.
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