High-sensitivity troponin I in patients with rhabdomyolysis acutely intoxicated with psychotropic and chemical substances
Journal
Clinical toxicology
Date Issued
2022-05-27
Author(s)
Jurukov, Irena
Naumoski, Kiril
Abstract
Objective: We determine high-sensitivity troponin I (hs-Tnl) activity in patients with rhabdomyolysis following acute intoxication
with psychotropic and chemical substances.
Methods: This is a clinically controlled prospective study conducted in 2019 at the University Clinic of Toxicology in Skopje. In
this study, 140 patients with rhabdomyolysis were divided into
two groups depending on the intoxicating substance i.e. psychotropic or chemical. Rhabdomyolysis was defined according to the
Poisoning Severity Score. High-sensitivity troponin (hs-TnI) was
measured in all patients with rhabdomyolysis three times, on the
first, third, and fifth days of hospitalization. Data were statistically
analyzed in SPSS software, version 22.0 for Windows (SPSS,
Chicago, IL, USA).
Results: In all patients with rhabdomyolysis, the mean hs-TnI
value on the first, third, and fifth days was 27.7 ± 78.3 mg/L,
43.7 ± 135.9 mg/L, and 28.73 ± 57.01 g/L, respectively. The comparison of hs-TnI in the three measurement times showed a significant difference (p ¼ 0.001). On the third day of hospitalization
in all patients the hs-TnI was significantly higher compared to
the fifth day (p ¼ 0.0001) as well as marginally insignificantly
higher compared to the first day (p ¼ 0.057). The value of hs-TnI
on the fifth day was insignificantly higher compared to the first
day (p ¼ 0.021). We determined the highest values of hs-TnI in
methadone intoxications (N ¼ 5, 279.7 ± 190.7 mg/L, other drugs
(N ¼ 1, 138.4 mg/L); and benzodiazepines (N ¼ 3, 213.9 ± 232.5 mg/
L). Analysis by type of intoxication on the first, third, and fifth
days showed that hs-TnI values were insignificantly higher in the
psychotropic group compared with the chemical intoxication
group.
Conclusion: The value of hs-TnI was slightly higher in patients
with rhabdomyolysis after acute psychotropic intoxication.
Elevated levels of hs-TnI in psychotropic intoxications were likely
related to the specific etiologies such as illicit substance use,
while chemical intoxication was associated with the clinical outcome of intoxication.
with psychotropic and chemical substances.
Methods: This is a clinically controlled prospective study conducted in 2019 at the University Clinic of Toxicology in Skopje. In
this study, 140 patients with rhabdomyolysis were divided into
two groups depending on the intoxicating substance i.e. psychotropic or chemical. Rhabdomyolysis was defined according to the
Poisoning Severity Score. High-sensitivity troponin (hs-TnI) was
measured in all patients with rhabdomyolysis three times, on the
first, third, and fifth days of hospitalization. Data were statistically
analyzed in SPSS software, version 22.0 for Windows (SPSS,
Chicago, IL, USA).
Results: In all patients with rhabdomyolysis, the mean hs-TnI
value on the first, third, and fifth days was 27.7 ± 78.3 mg/L,
43.7 ± 135.9 mg/L, and 28.73 ± 57.01 g/L, respectively. The comparison of hs-TnI in the three measurement times showed a significant difference (p ¼ 0.001). On the third day of hospitalization
in all patients the hs-TnI was significantly higher compared to
the fifth day (p ¼ 0.0001) as well as marginally insignificantly
higher compared to the first day (p ¼ 0.057). The value of hs-TnI
on the fifth day was insignificantly higher compared to the first
day (p ¼ 0.021). We determined the highest values of hs-TnI in
methadone intoxications (N ¼ 5, 279.7 ± 190.7 mg/L, other drugs
(N ¼ 1, 138.4 mg/L); and benzodiazepines (N ¼ 3, 213.9 ± 232.5 mg/
L). Analysis by type of intoxication on the first, third, and fifth
days showed that hs-TnI values were insignificantly higher in the
psychotropic group compared with the chemical intoxication
group.
Conclusion: The value of hs-TnI was slightly higher in patients
with rhabdomyolysis after acute psychotropic intoxication.
Elevated levels of hs-TnI in psychotropic intoxications were likely
related to the specific etiologies such as illicit substance use,
while chemical intoxication was associated with the clinical outcome of intoxication.
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