ENDOMETRIAL PATHOLOGICAL CHANGES IN PERIMENOPAUSE AND POSTMENOPAUSE - ASSOCIATION WITH SOME ANAMNESTIC AND ULTRASONOGRAPHIC PARAMETERS
Journal
Journal of Morphological Sciences
Date Issued
2022-05
Author(s)
Bashkim Ismaili
Dimitar Georgiev
DOI
10.55302/JMS2251028k
Abstract
Atypical endometrial hyperplasia is preneoplastic condition that precedes endometrioid
adenocarcinoma. Postmenopausal women should not have bleeding; the thickness of the endometrium is
normally below 5 mm and if it is above, the presence of a polyp, hyperplasia or cancer is suspected.
To determine the histopathological changes of the endometrium, the prevalence of functional and
organic changes and their association with history of previous childbirths and abortions, presence of
bleeding, intensity of bleeding, anteroposterior uterine diameter and endometrial thickness.
The study was performed in the Specialized Hospital for Gynecology and Obstetrics "Mother
Teresa" - Skopje and involved a total of 120 respondents who underwent fractionated explorative curettage
due to a medical indication.
They were divided into 2 groups: with functional and organic changes of the endometrium.
Ultrasonographic measurement of anteroposterior diameter of uterus and endometrial thickness was
performed.
The prevalence of functional changes was 30% and of organic changes 70%. The most common
histopathological diagnosis was an endometrial polyp (45% of women). The mean value of endometrial
thickness was 7.9 mm in the functional changes group and 13.6 mm in the organic changes group; this
difference was statistically significant (p <0.0001).
Perimenopausal patients had a significantly longer duration of bleeding than those in
postmenopause (p = 0.0009).
Endometrial adenocarcinoma was present in 3% of perimenopausal and in 5% of postmenopausal
patients. Endometrium was significantly thicker in women with organic changes than in those with
functional changes.
Perimenopausal patients had a significantly longer duration of bleeding, more intensive bleeding,
thicker endometrium and greater anteroposterior uterine diameter than those in postmenopause.
adenocarcinoma. Postmenopausal women should not have bleeding; the thickness of the endometrium is
normally below 5 mm and if it is above, the presence of a polyp, hyperplasia or cancer is suspected.
To determine the histopathological changes of the endometrium, the prevalence of functional and
organic changes and their association with history of previous childbirths and abortions, presence of
bleeding, intensity of bleeding, anteroposterior uterine diameter and endometrial thickness.
The study was performed in the Specialized Hospital for Gynecology and Obstetrics "Mother
Teresa" - Skopje and involved a total of 120 respondents who underwent fractionated explorative curettage
due to a medical indication.
They were divided into 2 groups: with functional and organic changes of the endometrium.
Ultrasonographic measurement of anteroposterior diameter of uterus and endometrial thickness was
performed.
The prevalence of functional changes was 30% and of organic changes 70%. The most common
histopathological diagnosis was an endometrial polyp (45% of women). The mean value of endometrial
thickness was 7.9 mm in the functional changes group and 13.6 mm in the organic changes group; this
difference was statistically significant (p <0.0001).
Perimenopausal patients had a significantly longer duration of bleeding than those in
postmenopause (p = 0.0009).
Endometrial adenocarcinoma was present in 3% of perimenopausal and in 5% of postmenopausal
patients. Endometrium was significantly thicker in women with organic changes than in those with
functional changes.
Perimenopausal patients had a significantly longer duration of bleeding, more intensive bleeding,
thicker endometrium and greater anteroposterior uterine diameter than those in postmenopause.
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