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Title: Comparison of ZAP-70/Syk mRNA levels with immunoglobulin heavy-chain gene mutation status and disease progression in chronic lymphocytic leukemia
Authors: Laurenti, Luca
Petlickovski, Aleksandar
Rumi, Carlo
Gobessi, Stefania
Piccioni, Paola
Tarnani, Michela
Puggioni, Pierluigi
Marietti, Sara
Sica, Simona
Leone, Giuseppe
Efremov, Dimitar G
Issue Date: Nov-2005
Journal: Haematologica
Abstract: The protein tyrosine kinase ZAP-70 has recently emerged as a major prognostic indicator in chronic lymphocytic leukemia (CLL). ZAP-70 is structurally and functionally homologous to Syk, a key mediator of B-cell receptor signaling. We therefore evaluated ZAP-70 expression in CLL B cells using Syk as an intracellular standard.
Appears in Collections:Faculty of Medicine: Journal Articles

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