Ве молиме користете го овој идентификатор да го цитирате или поврзете овој запис: http://hdl.handle.net/20.500.12188/17466
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dc.contributor.authorСтојаноски, Златеen_US
dc.contributor.authorГеоргиевски, Борчеen_US
dc.contributor.authorГенадиева-Ставриќ, Соњаen_US
dc.contributor.authorПивкова, Александраen_US
dc.contributor.authorЧадиевски, Лазарen_US
dc.date.accessioned2022-04-19T10:20:16Z-
dc.date.available2022-04-19T10:20:16Z-
dc.date.issued2011-12-
dc.identifier.urihttp://hdl.handle.net/20.500.12188/17466-
dc.description.abstractOral mucosistis is one of the most frequent complications in early post-transplant period after high-dose chemotherapy and stem cell transplantation. As result of toxic demage oral and gastrointestinal mucosal barier due to high dose chemotherapy, transplanted patients are at high risk of infective complications, sepsis, high-mortality and prolonged hospitalisation. Aim of study: to evaluate frequency of oral mucositis in our group of patients treated with higu dose hemotherapy and stem cells transplantation at University clinic of hematology, medical faculty Skopje, R.Macedonia. Material and method: during a 10 years period (from September 2000 to September 2010 we have performed 200 stem cell transplntations in patients with different hematological malignancies. Male 112 Female 88 Mediane age 34 years. (from 9-63 years). Distribution according to diagnosis AML 62%, ALL 8%, MM 10%, HD 8%, NHL 8%, other 2%. High-dose chemotherapy was used according to underlying disease. Median number of infused CD34 + cells= 3,42 x 10/6/ Kg bw. Engraftment was established on day +12. Standard prophylactic strategies in our center is to prepare oral solution consisted: hexaetidin, nystatin, lidocain and NHCO3. Results: oral mucositis is present in 50% of the patients. According to WHO scale system: 10pts gr.4, 15 pts gr.3, 30pts gr.2, 45 patients gr 1. oral mucositis. Conclusions: the frequency of mucositis in our center is sligtly lower than results from literature. This is probably due to oral solution prepared in our center. Application of New drug palifermin will further decreased the incidence of oral mucositis, incidence of infective complications and mortality in this group of patients.en_US
dc.language.isomken_US
dc.publisherSHMSHM / AAMDen_US
dc.relation.ispartofMEDICUSen_US
dc.subjectstem cell transplantationen_US
dc.subjectoral mucositisen_US
dc.titleОрален мукозитис - компликација на високодозна хемотерапија и трансплантација на матични клеткиen_US
dc.title.alternativeOral mucositis- complications of high-dose chemotherapy in stem cell transplantationen_US
dc.typeArticleen_US
item.grantfulltextnone-
item.fulltextNo Fulltext-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
crisitem.author.deptFaculty of Medicine-
Appears in Collections:Faculty of Medicine: Journal Articles
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