Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/17429
DC Field | Value | Language |
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dc.contributor.author | Stojanoski, Zlate | en_US |
dc.date.accessioned | 2022-04-18T08:22:56Z | - |
dc.date.available | 2022-04-18T08:22:56Z | - |
dc.date.issued | 2011-12-15 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/17429 | - |
dc.description.abstract | Background: Infections are frequent cause of further morbidity and mortality in stem cells recipients. Infection-related mortality is mainly due to severe bacterial sepsis, pneumonia and fungal infections. Case Report: We report a 60 years old patient with AML. In the complete remission he is received high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation. The patient was treated in sterile room, conditioned with HEPA filters. Antibiotic prophylaxis regimen consisted Ciprofloxacin 1.0 gr/day, Itraconazol 400 mg/day, Acyclovir 1500 mg/day, and Immunoglobulins IV 0.1 mg/kg once per week. From day +5 patient became febrile (Ne<0.5 x 103/mL). First line antibiotic regimen consisted third-generation anti-pseudomonal cephalosporine and amynoglicoside during a 72 h, but with no response. As a second line antibiotic therapy was introduced Vancomicyn 2.0 gr/day. On day +10 from blood culture and urine culture was isolated Stenotrophomonas maltophillia with in vitro succeptibilities only to Ciprofloxacin (+3). Co-trimoxasole and again Ciprofloxacin in maximal doses was administered, but patient deteriorate, and in sepsis with signes of endotoxic shock he die on day +15. Conclusion: Despite use of broad-spectrum antibiotics as prophylaxis, Gram-negative bacteria are still potentially fatal for immunocompromised patients. Microbiological monitoring on local microflora is mandatory for all transplant centers and intensive care units. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Macedonian Journal of Medical Sciences. | en_US |
dc.subject | stem cell transplantation | en_US |
dc.subject | infections | en_US |
dc.title | Fatal Sepsis Due to Stenotrophomonas Maltophilia in Stem Cell Recipient – Case Report | en_US |
dc.type | Article | en_US |
dc.identifier.doi | doi.org/10.3889/MJMS.1957-5773.2011.0194 | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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File | Description | Size | Format | |
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Stojanoski Z. Fatal Sepsis Due to Stenotrophomonas Maltophilia in Stem Cell Recipient – Case Report. Maced J Med Sci. 2011 Dec 15; 4(4)_408-410..html | 39.11 kB | HTML | View/Open |
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