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http://hdl.handle.net/20.500.12188/16795
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kostova, Elena | en_US |
dc.contributor.author | Shubeska Stratrova, Slavica | en_US |
dc.date.accessioned | 2022-03-02T09:03:49Z | - |
dc.date.available | 2022-03-02T09:03:49Z | - |
dc.date.issued | 2020 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/16795 | - |
dc.description.abstract | The aim of this study was to analyze TIMP-1 and TIMP-2 serum levels in patients with colorectal cancer (CRC) and to correlate the results with the pathological stage of the disease and outcome in order to evaluate the role of TIMP-1 and TIMP-2 serum levels as prognostic markers. The investigation has been made on 82 patients with operable CRC without distant metastases, who had undergone blood tests in order to determine the TIMP-1 and TIMP-2 serum levels in the following points of time: preoperatively, as well as 3, 6, 9 and 12 months postoperatively. Significant differences were found between serum levels of TIMP-1 and TIMP-2 obtained preoperatively and postoperatively, as well as significant association of serum TIMP-1 levels obtained preoperatively in CRC patients in stage I and III, in the 3th and in the 6th month (p<0.001) postoperatively as defined points of time with the outcome of CRC patients. Serum TIMP-2 levels obtained preoperatively was significantly associated with the outcome of the CRC patients. Analysis of the obtained TIMP-1 and TIMP-2 serum levels in CRC patients showed statistically significant differences with: disease progression, occurrence of liver metastasis, prior to and post chemotherapy treatment. The results derived a conclusion that the serum levels of TIMP-1 and TIMP-2 could be indicators for occurrence and progression of CRC, as well as valuable and useful markers for following the effects of chemotherapy treatment. | en_US |
dc.language.iso | en_US | en_US |
dc.relation.ispartof | Macedonian pharmaceutical bulletin | en_US |
dc.subject | colorectal cancer | en_US |
dc.subject | TIMP-1 | en_US |
dc.subject | TIMP-2 | en_US |
dc.subject | prognosis | en_US |
dc.title | Prognostic meaning of tissue inhibitors of matrix metalloproteinases TIMP-1 and TIMP-2 in patients with colorectal cancer | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.33320/maced.pharm.bull.2020.66.01.003 | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
Files in This Item:
File | Опис | Size | Format | |
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Prognostic meaning of tissue inhibitors of matrix.pdf | 585.67 kB | Adobe PDF | View/Open |
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