DEEP VEIN THROMBOSIS AND RECURENT PULMONARY EMBOLISM IN A PATIENT WITH THROMBOPHILIC MUTATIONS AND GENERALIZED PSORIASIS: A CASE REPORT
Journal
SANAMED
Date Issued
2020-07-29
Author(s)
Baloski, Marjan
Brishkoska Boshkovski, Vesna
Hasan, Taner
Nedeska Minova, Natasha
Nanceva Bogoevska, Andrea
Panov, Saso
DOI
10.24125/sanamed.v15i2.391
Abstract
Introduction: Genetic risk factors that
increase venous thromboembolism risk are disorders
in the synthesis or activity of coagulation factors. Fac-
tor V Leiden, prothrombin (20210-A), antithrombin
deficiency, protein C and protein S deficiency, and
hyperhomocysteinaemia are the most common venous
thromboembolism-related gene mutations. When ge-
netic factors are combined with non-provoking risk
factors (obesity, psoriasis, smoking and previous veno-
us thromboembolism) the result is increased venous
thromboembolism risk for each factor individually.
Previous venous thromboembolism is one of the stron-
gest risk factors, even in patients actively treated with
anticoagulant. Patients are more likely to have recur-
rent venous thromboembolism with longer duration.
Psoriasis is a complex immune–mediated disease, as-
sociated with cardiovascular risk, hypercoagulability
markers and elevated homocysteine. Lots of observati-
onal reports suggest increased incidence of venous
trombembolic events in patient with psoriasis
increase venous thromboembolism risk are disorders
in the synthesis or activity of coagulation factors. Fac-
tor V Leiden, prothrombin (20210-A), antithrombin
deficiency, protein C and protein S deficiency, and
hyperhomocysteinaemia are the most common venous
thromboembolism-related gene mutations. When ge-
netic factors are combined with non-provoking risk
factors (obesity, psoriasis, smoking and previous veno-
us thromboembolism) the result is increased venous
thromboembolism risk for each factor individually.
Previous venous thromboembolism is one of the stron-
gest risk factors, even in patients actively treated with
anticoagulant. Patients are more likely to have recur-
rent venous thromboembolism with longer duration.
Psoriasis is a complex immune–mediated disease, as-
sociated with cardiovascular risk, hypercoagulability
markers and elevated homocysteine. Lots of observati-
onal reports suggest increased incidence of venous
trombembolic events in patient with psoriasis
File(s)![Thumbnail Image]()
Loading...
Name
391-2449-1-PB.pdf
Size
157.38 KB
Format
Adobe PDF
Checksum
(MD5):4ebef95894672f07b5df54c9fbad3953