Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12188/16472
Title: Prevalence of Rotaviruses in the Etiology of Acute Diarrhea in Young Children, Clinical forms, Extraintestinal Manifestations and Complications
Authors: Stojkovska, Snezhana 
Kondova-Topuzovska I 
Milenkovikj, Zvonko 
Bosilkovski, Mile 
Grozdanovski, Krsto 
Cvetanovska, Marija 
Dimzova, Marija 
Petrusevska-Marinkovic, Sanja
Stevanovikj, Milena
Demiri, Ilir 
Bogoevska-Tasevska, Sunchica
Semenakova-Cvetkovska, Vesna
Kirova-Uroshеvikj, Valerija
Spasovska, Katerina 
Saveski, Velimir
Keywords: clinical manifestations
complications
rotavirus
immunization
incidence
prevention
Issue Date: 8-Dec-2020
Publisher: Macedonian Academy of Sciences and Arts/Sciendo
Source: Stojkovska S, Kondova-Topuzovska I, Milenkovikj Z, Bosilkovski M, Grozdanovski K, Cvetanovska M, Dimzova M, Petrusevska-Marinkovic S, Stevanovikj M, Demiri I, Bogoevska-Tasevska S, Semenakova-Cvetkovska V, Kirova-Uroshеvikj V, Spasovska K, Saveski V. Prevalence of Rotaviruses in the Etiology of Acute Diarrhea in Young Children, Clinical forms, Extraintestinal Manifestations and Complications. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2020 Dec 8;41(3):23-30. doi: 10.2478/prilozi-2020-0042. PMID: 33500370.
Journal: Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki) 
Abstract: Rotavirus is highly contagious factor with dominant feces-oral transmission. Because it is stable in external environment, transmission clusters are possible by close contact, ingestion of contaminated water or food or contact with contaminated surfaces. It survives within hours and days on hands and contaminated surfaces. This makes it the most common enteric and nosocomial pathogen in the world, especially in early childhood. In addition to the rapid dehydration with pronounced electrolyte disturbances, numerous extraintestinal possibilities have been recorded in the clinical picture, which emphasizes the need for prevention of this disease.In the period from 1.02.2018 to 31.01.2020 at the Clinic for Infectious diseases were treated 1060 patients with diarrheal disease, of which 502 children (47.36%). Rotavirus etiology was confirmed in 23.30% of the children. According to the protocols, laboratory and biochemical investigations were done to all 117 children, with tracking parameters and their dynamics of admission and discharge from the hospital. Most of the children, 84 (82.0 6%) are from urban areas, with a more confirmed epidemiological survey of 59 (42.00%). The average age of the children was 8 months, with a small percentage of children on maternal food (breastfed 25, i.e. 21.37%), with high febrile admission in 99% of children with an average temperature of 38.5oC and an average febrile duration of 4 days, with an average of 7 (+ 2.49) of stools and 5 (+ 2.12) of vomiting. There was a significant difference in hematocrit, leukocyte, electrolyte, glycaemia, and CRP values on admission and discharge. There was predominant isonatremic dehydration, and the compensatory mechanisms followed by the values of the electrolytes ABS, Ph, BE showed a tendency to maintain within the physiological limits. The clinical picture of extraintestinal manifestations included bronchitis, mesenteric lymphadenitis, upper respiratory infections and rash.Rotavirus infection is a serious health and economic problem in our country, so it needs continuous prevention and monitoring in order to reduce the incidence, and thus the need for hospitalization and cure of rotavirus disease.
URI: http://hdl.handle.net/20.500.12188/16472
Appears in Collections:Faculty of Medicine: Journal Articles

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