DIAGNOSTIC UTILITY OF ANTI-CCP ASSAY IN PATIENTS WITH RHEUMATOID ARTHRITIS
Journal
Acta Morphologica
Date Issued
2021-12
Author(s)
Krstevska Balkanov, Svetlana
Abstract
Introduction: The purpose of this research was to compare the diagnostic values of laboratory variables, to present quantitative evaluations of the diagnostic test with reference value for anti-cyclic citrullinated peptide (anti-CCP2) antibodies, rheumatoid factor (RF), Creactive protein (CRP), and DAS 28 index in early diagnosis of untreated rheumatoid arthritis (RA). Material and methods: Using the ELISA method of DIA-STAT™ Anti CCP (Axis-Shield Diagnostics), sera of 70 participants were examined (35 untreated patients with RA and 35 subjects from the healthy control group). RF and CRP were determined with the agglutination test (Latex test) in the same participants. At the same time, we determined the sensitivity, specificity, predictive value for positive and negative test and accuracy. Results: Presence of anti-CCP 2 antibodies was 65.71%, 23/35 patients, while RF was present in 17/35 (48.57%). Twelve patients were anti-CCP2 and RF positive, 11 were antiCCP2 positive, but RF negative. Five patients were anti-CCP2 negative and RF positive. In the healthy control group, one patient was anti-CCP2 positive, while 2 patients were RF positive. Conclusion: Anti-CCP2 antibodies have higher sensitivity and specificity than RF in early RA
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