On the hydrates of codeine phosphate: the remarkable influence of hydrogen bonding on the crystal size

Runčevski, Tomče; Petruševski, Gjorgji; Makreski, Petre; Ugarkovic, Sonja; Dinnebier, Robert E

doi:10.1039/c4cc01430h

On the hydrates of codeine phosphate: the remarkable influence of hydrogen bonding on the crystal size

Journal

Chemical communications (Cambridge, England)

Date Issued

2014-07-07

Author(s)

Runčevski, Tomče

Petruševski, Gjorgji

Ugarkovic, Sonja

Dinnebier, Robert E

DOI

10.1039/c4cc01430h

Abstract

Codeine phosphate forms three hydrates and two anhydrates. The sesquihydrate and hemihydrate, which differ by one water molecule, are stable at room temperature. The influence of this molecule on the internal crystal structure and how it translates into the external crystal shape are reported.