GANGLIOMA ASSOCIATED WITH FOCAL EPILEPSY
Journal
Македонски медицински преглед = Macedonian medical review
Date Issued
2020
Author(s)
Lejla Muaremoska Kanzoska
Learta Adili Ademi
Matilda Stojanovska
Maja Tankoska
Julijana Georgievska
Ivona Petkovska Ivanovska
Abstract
Although rare, gangliomas represent the most common
tumor entity in young patients suffering from focal
epilepsy [1,2].
The current World Health Organization (WHO) classi-
fication defines ganglioglioma (GG) as a neoplasm com-
posed of neural (ganglion cells) and glial elements, with
both components being neoplastic [3].Ganglioglioma
accounts for 0.4% to 9% of primary brain tumors and
has been described in all parts of the central nervous
system, but most commonly comes to clinical attention
when present in the cerebral hemispheres, particularly
in the temporal lobe [4,5].
We present a 13-year-old boy with repetitive focal
seizures. The implemented EEG revealed right focus
ofspike-wave complexes. Contrast-enhancedmagnetic
resonance showed findings of TU lesion in the right
middle temporal lobe. The patient underwent tumor
excision. Patohistological diagnosis of the resected tu-
mor was ganglioglioma. Postoperatively, the patient
wasseizure-free, but the control EEG wasthe same
asthe first EEG.
In patients with ganglioglioma the appropriate treatment
strategy involves not only the complete surgical extir-
pation of the tumor, but also relatively early surgical
intervention, because such an approach provides maxi-
mum chance of an epilepsy cure [6].
tumor entity in young patients suffering from focal
epilepsy [1,2].
The current World Health Organization (WHO) classi-
fication defines ganglioglioma (GG) as a neoplasm com-
posed of neural (ganglion cells) and glial elements, with
both components being neoplastic [3].Ganglioglioma
accounts for 0.4% to 9% of primary brain tumors and
has been described in all parts of the central nervous
system, but most commonly comes to clinical attention
when present in the cerebral hemispheres, particularly
in the temporal lobe [4,5].
We present a 13-year-old boy with repetitive focal
seizures. The implemented EEG revealed right focus
ofspike-wave complexes. Contrast-enhancedmagnetic
resonance showed findings of TU lesion in the right
middle temporal lobe. The patient underwent tumor
excision. Patohistological diagnosis of the resected tu-
mor was ganglioglioma. Postoperatively, the patient
wasseizure-free, but the control EEG wasthe same
asthe first EEG.
In patients with ganglioglioma the appropriate treatment
strategy involves not only the complete surgical extir-
pation of the tumor, but also relatively early surgical
intervention, because such an approach provides maxi-
mum chance of an epilepsy cure [6].