Procalcitonin-early biochemical marker for diagnosis, prognosis and treatment of sepsis in neonates and oncological patients with febile neutropenia
Journal
Journal of Morphological Sciences
Date Issued
2020
Author(s)
Tankoska Maja
Kimovska Hristova, Mica
Voinovska, Tamara
Neshkova, S.
Antevska, Z.
Jovanovska, A.
Teov, B.
Micevska - Kostadinova, L.
Abstract
Pediatric sepsis is a life
-
threatening condition, in which the immune system, instead of
controlling the infection,causes
damage to tissues and organs. The aim of this study was to determine
the role of procalcitonin
(PCT)in the early diagnosis of sepsis in high
-
risk infants and Oncological
patients with febrile neutropenia,its prognostic value,and the role of PCT in the cho
ice of antibiotic.
The study is designed as retrospective
-
prospective, it is being worked
at
the PHI
UC
for
Children Diseases
Skopje.
I
t includes 60 critical newborns and 40
O
ncology patients.The examined
group
were
divided into two subgroups:30 critical
i
nfants with bacterial sepsis in the intensive care
unit
and
20
O
ncological patients with sepsis
and
febrile neutropenia.
PCT was determined the first
24h,3
-
5 days and 6
-
14 days of hospitalization.
The value of PCT during the first 24 hours of admission
was
increased in all
50
patients
.Most of them had
signs of severe sepsis
and few od them had
signs of
septic shock
.
In all of them,
double parenteral antibiotic therapy was started
.Seven
patients has
died
in
the first five days.
After
3
-
5 days
of
the start of antibiotic therapy,
PC
T
values
decreased
.
After the
third measurement, PCT
values
continued to decrease
and
in majority of the patients the antibiotic
therapy was discontinued.
By measuring the values
of PCT,
an early diagnosis of sepsis
can be made.
This is important
to start with antibiotics to prevent sepsis and septic shock
.
T
he dynamic in the values
of
PCT
determine the duration of antibiotic,its modification,the rational uses of antibiotics and the emergence
of resistance to it.
-
threatening condition, in which the immune system, instead of
controlling the infection,causes
damage to tissues and organs. The aim of this study was to determine
the role of procalcitonin
(PCT)in the early diagnosis of sepsis in high
-
risk infants and Oncological
patients with febrile neutropenia,its prognostic value,and the role of PCT in the cho
ice of antibiotic.
The study is designed as retrospective
-
prospective, it is being worked
at
the PHI
UC
for
Children Diseases
Skopje.
I
t includes 60 critical newborns and 40
O
ncology patients.The examined
group
were
divided into two subgroups:30 critical
i
nfants with bacterial sepsis in the intensive care
unit
and
20
O
ncological patients with sepsis
and
febrile neutropenia.
PCT was determined the first
24h,3
-
5 days and 6
-
14 days of hospitalization.
The value of PCT during the first 24 hours of admission
was
increased in all
50
patients
.Most of them had
signs of severe sepsis
and few od them had
signs of
septic shock
.
In all of them,
double parenteral antibiotic therapy was started
.Seven
patients has
died
in
the first five days.
After
3
-
5 days
of
the start of antibiotic therapy,
PC
T
values
decreased
.
After the
third measurement, PCT
values
continued to decrease
and
in majority of the patients the antibiotic
therapy was discontinued.
By measuring the values
of PCT,
an early diagnosis of sepsis
can be made.
This is important
to start with antibiotics to prevent sepsis and septic shock
.
T
he dynamic in the values
of
PCT
determine the duration of antibiotic,its modification,the rational uses of antibiotics and the emergence
of resistance to it.