C-reactive protein predicts all-cause mortality in hemodialysis patients
Journal
BANTAO Journal
Date Issued
2005
Author(s)
Grozdanovski, R
Amitov, V
Gelev, S
Abstract
Mortality in dialysis patients remains extremely high
despite significant improvements in the provision of
dialysis over the past 20 years. It once was believed that
factors related to dialysis treatment and technique were the
main causes of poor clinical outcome, but a recent
multicenter, randomized clinical trial known as the HEMO
Study failed to show an improvement in mortality or
hospitalization by increasing dialysis dose or using high-
flux dialysis membranes1. The medical determinants of
mortality in dialysis patients are well appreciated, but
available evidence suggests that among potential
candidates for the high rate of hospitalization and mortality
in dialysis patients both malnutrition and inflammation
continue to be at the top of the list. Epidemiological
studies repeatedly and consistently have shown a strong
association between clinical outcome and inflammation in
dialysis patients 2, 3. Our study objective was to evaluate the
factors associated with all-cause mortality in a cohort of
hemodialysis patients treated in a single hemodialysis
center
despite significant improvements in the provision of
dialysis over the past 20 years. It once was believed that
factors related to dialysis treatment and technique were the
main causes of poor clinical outcome, but a recent
multicenter, randomized clinical trial known as the HEMO
Study failed to show an improvement in mortality or
hospitalization by increasing dialysis dose or using high-
flux dialysis membranes1. The medical determinants of
mortality in dialysis patients are well appreciated, but
available evidence suggests that among potential
candidates for the high rate of hospitalization and mortality
in dialysis patients both malnutrition and inflammation
continue to be at the top of the list. Epidemiological
studies repeatedly and consistently have shown a strong
association between clinical outcome and inflammation in
dialysis patients 2, 3. Our study objective was to evaluate the
factors associated with all-cause mortality in a cohort of
hemodialysis patients treated in a single hemodialysis
center