DEFINITIVE TREATMENT OF PLANOCELLULAR OROPHARYNGEAL CARCINOMA WITH MODERATE ACCELERATION OF INTENSITY MODULATED RADIATION THERAPY WITH SIMULTANEOUS INTEGRATED BOOST
Journal
Acta Morphologica
Date Issued
2020
Author(s)
Kostadinova, Lenche
Stoleska, Marina
Abstract
Introduction: Intensity Modulated Radiation Therapy (IMRT) represents a new technique
in the treatment of head and neck carcinomas. Oropharyngeal carcinomas are ideal target for
this radiation technique, because of their anatomic localization close to critical healthy organs.
Simultaneous Integrated Boost (SIB) in IMRT allows in at the same time at the same fraction
delivering of different dose to different structures to irradiated volume with distribution on
higher dose to the tumor and lower dose in elective irradiated regions. Moderate acceleration
of IMRT-SIB allows in shorter time delivering of higher dose to planning target volume and
achieving bigger tumor control.
Objective: Aim of this study was to present planning technique IMRT – SIB with 95%
dose coverage of volume of planning target volumes referring to primary oropharyngeal
carcinoma, metastatic lymph nodes, elective region in head and neck which is irradiated and to
critical organs near the tumor, achieving in the future better tumor control and fewer side effects
on healthy tissues.
Materials and methods: This retrospective study included 31 patients with advanced
planocellular oropharyngeal cancer treated at University clinic of Radiotherapy and oncology-
Skopje, with modulate acceleration of IMRT-SIB and weekly concurrent cisplatin.
Results: With IMRT SIB we achieved high 95% dose coverage of the planned target
volumes (PTV54 = 99,46 % and PTV66 = 98.74 %) and successfully spare the spinal cord as
the most important organ at risk.
Conclusion: IMRT- SIB fulfill the goal of better tumor coverage and moderate acceleration
achieve dose reduction in critical healthy organs.
in the treatment of head and neck carcinomas. Oropharyngeal carcinomas are ideal target for
this radiation technique, because of their anatomic localization close to critical healthy organs.
Simultaneous Integrated Boost (SIB) in IMRT allows in at the same time at the same fraction
delivering of different dose to different structures to irradiated volume with distribution on
higher dose to the tumor and lower dose in elective irradiated regions. Moderate acceleration
of IMRT-SIB allows in shorter time delivering of higher dose to planning target volume and
achieving bigger tumor control.
Objective: Aim of this study was to present planning technique IMRT – SIB with 95%
dose coverage of volume of planning target volumes referring to primary oropharyngeal
carcinoma, metastatic lymph nodes, elective region in head and neck which is irradiated and to
critical organs near the tumor, achieving in the future better tumor control and fewer side effects
on healthy tissues.
Materials and methods: This retrospective study included 31 patients with advanced
planocellular oropharyngeal cancer treated at University clinic of Radiotherapy and oncology-
Skopje, with modulate acceleration of IMRT-SIB and weekly concurrent cisplatin.
Results: With IMRT SIB we achieved high 95% dose coverage of the planned target
volumes (PTV54 = 99,46 % and PTV66 = 98.74 %) and successfully spare the spinal cord as
the most important organ at risk.
Conclusion: IMRT- SIB fulfill the goal of better tumor coverage and moderate acceleration
achieve dose reduction in critical healthy organs.