Ве молиме користете го овој идентификатор да го цитирате или поврзете овој запис: http://hdl.handle.net/20.500.12188/14614
Наслов: Relationship between Vitamin D, Inflammation and Lung Function In Patients with Severe Uncontrolled Asthma
Authors: Jovanovska-Janeva, Elena 
Dokic, Dejan 
Jovkovska-Kaeva, Biserka
Breskovska, Gorica
Goseva, Zlatica
Minov, Jordan 
Trajkov, Dejan 
Genadieva-Dimitrova, Magdalena 
Zafirovska-Ivanovska, Beti 
Keywords: asthma
vitamin D
IL-33
FEV1
Th2-type cytokines
Issue Date: 15-дек-2017
Publisher: Scientific Foundation SPIROSKI
Journal: Open Access Macedonian Journal of Medical Sciences 
Abstract: BACKGROUND:Recently epidemiological studies showed that low vitamin D is linked toairway hyperresponsiveness, decreasedlung function, poor asthma control, and steroid–resistant asthma.AIM:We investigatedtherelationshipbetween Vitamin D, inflammation with circulating IL-33 and lung function in 30 patients with severe uncontrolled asthma. MATERIALS AND METHODS:The study included 30 patients with severe uncontrolled asthma. In each of them were measured serum levels of IL-33 and Vitamin D by the ELISA method. The pulmonary function is measuredby basic spirometry parameters, FEV1. The results were statistically elaboratedaccording to the Pearson’s Correlation Tests. RESULTS:The results showed statistically insignificant correlation between Vitamin D and IL-33, and Vitamin D with FEV1 (Vit.D/IL-33; r=0.11323, p=0.551); (Vit.D/FEV1; r=-0.1005; p=0.597) Correlation between IL-33 and FEV1 is negative but statistically significant (IL-33/FEV1; r=-0.5248; p=0.003). CONCLUSION:Because there arelittle studies about the link between vitamin D and asthma, further research toclarify the mechanism how vitamin D control the activity of CD4+ T cells and the related Th2-type cytokines in the parthenogenesis of asthma.
URI: http://hdl.handle.net/20.500.12188/14614
ISSN: 1857-9655
DOI: 10.3889/oamjms.2017.190
Appears in Collections:Faculty of Medicine: Journal Articles

Прикажи целосна запис

Page view(s)

91
checked on 9.7.2025

Google ScholarTM

Проверете

Altmetric


Записите во DSpace се заштитени со авторски права, со сите права задржани, освен ако не е поинаку наведено.