Fibrillary Nephropathy and Amyloidosis - Two Morphological Faces of the Myeloma Kidney
Journal
BANTAO Journal
Date Issued
2020
Author(s)
Abstract
Myeloma-induced renal failure is associated with sig-
nificant morbidity and mortality. Rapid intervention is
critical to reverse kidney damage and improve renal
function. We report two cases, one with fibrillary
nephropathy and other one with kidney amyloidosis
due to multiple myeloma, diagnosed by renal biopsy
and treated in our department. Both patients had no
other signs of multiple myeloma present, apart from
acute renal failure and histological findings on renal
biopsy. The renal biopsy was performed because of acute
renal failure to exclude rapidly progressive glomerulo-
nephritis. The histological analysis showed fibrillary
glomerulopathy in one patient and kidney amyloidosis
in the other, changes consistent with the diagnosis of
multiple myeloma with kidney involvement. Further
clinical investigation confirmed multiple myeloma and
the patients treated accordingly.
nificant morbidity and mortality. Rapid intervention is
critical to reverse kidney damage and improve renal
function. We report two cases, one with fibrillary
nephropathy and other one with kidney amyloidosis
due to multiple myeloma, diagnosed by renal biopsy
and treated in our department. Both patients had no
other signs of multiple myeloma present, apart from
acute renal failure and histological findings on renal
biopsy. The renal biopsy was performed because of acute
renal failure to exclude rapidly progressive glomerulo-
nephritis. The histological analysis showed fibrillary
glomerulopathy in one patient and kidney amyloidosis
in the other, changes consistent with the diagnosis of
multiple myeloma with kidney involvement. Further
clinical investigation confirmed multiple myeloma and
the patients treated accordingly.