DIAGNOSTIC CENTRAL OBESITY INDEXES CUT – OFF POINT VALUES DETERMINED WITH DUAL-ENERGY X-RAY ABSORPTIOMETRY IN CUSHING’S AND OBESE WOMEN
Journal
Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)
Date Issued
2020
Author(s)
Abstract
Aim: The aim of this study was to develop quantiative criteria for defining visceral obesity and to establish
dual-energy X-ray absorptiometric (DXA) diagnostic cut-off points (CP) for normal and abnormal values
of the central obesity indexes (COI) that best differentiate extreme visceral obesity in Cushing’s syndrome
(CS) from non CS obese and non obese women.
Material and Methods: COI1–4 values calculated as a ratio of android to gynoid tissue mass, fat mass and
their % were determined in 4 groups, each consisting of 18 women: 1st group of CS, 2nd group of obese
women (O1
) not different according to their age and BMI from CS, 3rd group of obese women (O2
) with
BMI of 35 ± 1.2 kg and 4th group of non obese healthy women (C) with normal BMI. Diagnostic accuracy
(DG) of CP values of COI1m-4m indexes of abdominal obesity and CP values of COI1n-4n indexes of normal
body fat distribution (BFD) was determined.
Results: COI1-4 indexes values were highly significantly different among the 4 examined groups and were
significantly highest in CS patients and lowest in group C (p < 0.0001). COI1m-4m CP values differentiated
extreme visceral, abdominal obesity in CS with highest DG as well as COI1n-4n CP values differentiated
normal BFD in group C. COI1m CP of 0.55 best differentiated CS from O1
for DG of 100%. COI2n of 0.38
best differentiated C from CS and O2
for highest DG of 100% compared to O1
because of the significantly
higher BMI and COI1n-4n values in O2
that were associated with more pronounced abdominal obesity and
highly significantly positive correlation with BMI.
Conclusions: DXA cut-off point values of indexes COI1m-4m and COI1n-4n were established as diagnostic
indexes and criteria useful in discovering extreme abdominal and normal BFD. COI1m CP value of 0.55
was discovered as a diagnostic criterion of extreme abdominal obesity and COI2n of 0.38 as a diagnostic
criterion of normal BFD that excluded abdominal obesity. The other indexes COI1m-4m and COI1n-4n CP
values had also high DG in discovering abdominal and normal body fat distribution.
dual-energy X-ray absorptiometric (DXA) diagnostic cut-off points (CP) for normal and abnormal values
of the central obesity indexes (COI) that best differentiate extreme visceral obesity in Cushing’s syndrome
(CS) from non CS obese and non obese women.
Material and Methods: COI1–4 values calculated as a ratio of android to gynoid tissue mass, fat mass and
their % were determined in 4 groups, each consisting of 18 women: 1st group of CS, 2nd group of obese
women (O1
) not different according to their age and BMI from CS, 3rd group of obese women (O2
) with
BMI of 35 ± 1.2 kg and 4th group of non obese healthy women (C) with normal BMI. Diagnostic accuracy
(DG) of CP values of COI1m-4m indexes of abdominal obesity and CP values of COI1n-4n indexes of normal
body fat distribution (BFD) was determined.
Results: COI1-4 indexes values were highly significantly different among the 4 examined groups and were
significantly highest in CS patients and lowest in group C (p < 0.0001). COI1m-4m CP values differentiated
extreme visceral, abdominal obesity in CS with highest DG as well as COI1n-4n CP values differentiated
normal BFD in group C. COI1m CP of 0.55 best differentiated CS from O1
for DG of 100%. COI2n of 0.38
best differentiated C from CS and O2
for highest DG of 100% compared to O1
because of the significantly
higher BMI and COI1n-4n values in O2
that were associated with more pronounced abdominal obesity and
highly significantly positive correlation with BMI.
Conclusions: DXA cut-off point values of indexes COI1m-4m and COI1n-4n were established as diagnostic
indexes and criteria useful in discovering extreme abdominal and normal BFD. COI1m CP value of 0.55
was discovered as a diagnostic criterion of extreme abdominal obesity and COI2n of 0.38 as a diagnostic
criterion of normal BFD that excluded abdominal obesity. The other indexes COI1m-4m and COI1n-4n CP
values had also high DG in discovering abdominal and normal body fat distribution.
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