Faculty of Medicine
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Item type:Publication, MANAGEMENT OF TWO IVF PREGNANCIES IN A PATIENT WITH A BICORNUATE UTERUS WITH ONE CERVIX AND A TOTAL OCCLUSION OF BOTH TUBES(SHMSHM - AAMD, 2026); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, PREMATURE BIRTH AS A RESULT OF CONGENITAL ANOMALY IN A UNICORN UTERUS(Walter de Gruyter GmbH, 2025-05-16); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, APGAR SCORE AT THE FIRST AND FIFTH MINUTE AS A PREDICTOR OF SURVIVAL AND INCREASED NEONATAL MORTALITY IN NEWBORNS TREATED IN THE NICU(Walter de Gruyter GmbH, 2025-05-16); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, CONTINUOUS INTRAVENOUS NIMODIPINE APPLICATION FOR PREVENTION OF VASOSPASM BEFORE ENDOVASCULAR TREATMENT OF RUPTURED CEREBRAL ANEURISMS(Macedonian Association of Anatomists and Morphologists, 2022); ; ; - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Association between endometrial heterogeneity and endometrial cancer risk stratification in postmenopausal women(Srpsko lekarsko društvo, Beograd, 2026); ; ; ; SUMMARY Introduction/Objective The normal postmenopausal endometrium typically appears thin, homogeneous, and echogenic on transvaginal ultrasonography. In contrast, endometrial carcinoma is often associated with increased thickness, heterogeneous echogenicity, irregular endometrial–myometrial interface, and enhanced Doppler vascularization. The objective of this study was to evaluate the association between heterogeneous endometrial echogenicity and the risk of endometrial malignancy in postmenopausal women. Methods This prospective clinical study included 120 postmenopausal women treated at the University Clinic for Gynecology and Obstetrics in Skopje. Participants were divided into a control group (n = 40) and an examined group (n = 80). The examined group was further stratified according to uterine bleeding status and endometrial thickness (5–8 mm, > 8–11 mm, and > 11 mm). Endometrial echogenicity was assessed by transvaginal ultrasonography and classified as homogeneous or heterogeneous. Binary logistic regression analysis was performed to determine independent predictors of malignancy. Results Heterogeneous endometrial echogenicity was significantly more frequent in the examined group compared with controls (p < 0.001). It was identified as an independent predictor of endometrial malignancy (OR = 4.938; 95% CI: 1.24–19.62; p = 0.023). No statistically significant association was observed between echogenicity and endometrial thickness subgroups (p = 0.49) or uterine bleeding status (p = 0.82). Conclusion Heterogeneous endometrial echogenicity represents a significant independent sonographic predictor of endometrial malignancy in postmenopausal women and should be incorporated into routine ultrasound risk assessment. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ASSOCIATION BETWEEN PREMATURITY AND NEONATAL MORTALITY IN OUR MATERIAL(Walter de Gruyter GmbH, 2025-05-02); - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Sonographic evaluation of the mechanism of labor - our preliminary experience(Faculty of Medicine, 2026-05-22); ; ; Kijajova IvanaIntroduction: Intrapartum ultrasound evaluation is a contemporary diagnostic tool that provides insight into the process of normal labor and assists in its monitoring. Standardized mathematical parameters are used to assess the relationship between defined landmarks on the fetal head and structures of the soft and bony tissues of the birth canal. Aim: This study was designed to show that intrapartum sonographic parameters, primarily the angle of progression and the distance between the fetal head and maternal perineum, are equally effective in the management of labor progress, as vaginal digital examinations. Material and methods: A prospective cohort study was conducted involving 50 laboring women who were admitted at the delivery department of the University Clinic for Obstetrics and Gynecology in Skopje. They were all in the active stage of labor and were evaluated with intrapartum ultrasound, both transabdominal and transperineal, during the first, second and third hours after admission. Results: An increase in the angle of progression and a decrease in the distance between the fetal head and the maternal perineum can help in predicting the mode of delivery and the time interval to delivery. Conclusion: Introducing intrapartum ultrasound as a complementary tool to the digital vaginal examinations, offers new perspectives in the perinatology, with a unique opportunity for modification and modernization of the traditional protocols for management of labor and delivery, still used across the modern countries worldwide. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, ALDOSTERONE SYNTHASE DEFICIENCY FROM HOMOZYGOUS CYP11B2 MUTATION PRESENTING WITH SALT WASTING CRISIS AND FAILURE TO THRIVE IN AN INFANT(Department of Anaesthesia and Reanimation, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, R.N. Macedonia, 2025-12-17); ; Spasevska, SimonidaAbstract Introduction: Aldosterone synthase deficiency (ASD) is a rare autosomal recessive disorder caused by pathogenic variants in the CYP11B2 gene, leading to impaired aldosterone synthesis and life-threatening salt-wasting. We present a case of an infant with failure to thrive, dehydration, and electrolyte imbalance, diagnosed through next-generation sequencing. Material and Methods: mitted with persistent vomiting, constipation, and a10% weight loss. Laboratory evaluation showed severe hyponatremia (116 mmol/L), hyperkalemia (6.5 mmol/L), hypochloremia (87 mmol/L), and metabolic alkalosis. Differential diagnosis included gastrointestinal loss, renal salt-wasting, cystic fibrosis, celiac disease, and congenital adrenal hyperplasia. Normal 17-hydroxyprogesterone excluded classical CAH. Next-generation sequencing was performed. Results: A homozygous pathogenic variant c.554C>T (p.Thr185Ile) in CYP11B2 confirmed ASD. Treatment with fludrocortisone and sodium supplementation resulted in rapid correction of electrolytes and improved growth. Follow-up at 3.5 years showed normal growth (14.5 kg, 103 cm), stable electrolytes, and normal development, with only mild transient hyponatremia during illness. Conclusion: ASD should be considered in infants with vomiting, dehydration, and combined hyponatremia–hyperkalemia when CAH is excluded. Early diagnosis and mineralocorticoid therapy prevent complications and support normal development. - Some of the metrics are blocked by yourconsent settings
Item type:Publication, Population pharmacokinetics of intravenous moxifloxacin in hospitalized patients with acute exacerbation of COPD(Macedonian Pharmaceutical Association, Ss. Cyril and Methodius University in Skopje, Faculty of Pharmacy, 2026); ; Evgenija Mihajlovska