NEURO DEVELOPMENTAL CONSEQUENCES OF NEONATAL HYPOGLYCEMIA
Journal
Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)
Date Issued
2020-09
Author(s)
Valentina Dukovska
DOI
10.2478/prilozi-2020-0037
Abstract
Neonatal hypoglycemia (HG) can cause neurologic damage, epilepsy, mental retardation, behavioral and
personality disorders and death. The longest the HG lasts and the greatest the glucose nadir the consequences are more pronounced.
Comorbidities are rather important in development of neurological damage. Hypoxemia and ischemia can
cause permanent brain damage. Small for gestational age (SGA), large for gestational age (LGA), intrauterine growth restriction, gestational age bellow the 37th week, low Apgar score, sepsis, children whose
mothers have toxemia, diabetes or chorioamnionitis are all newborns with increased HG risk.
Comparing 34 patients with NH and 34 children without NH with similar GA, BW, BL, the Apgar score,
we found statistically significant differences in motor and mental development using the Griffith scale.
Children with neonatal HG fared significantly worse than those without neonatal HG. Therefore, CBG
measurements and early recognition of neonatal HG is of significant importance in preventing motor and
mental damage in children. A larger and well-balanced cohort of patients followed for a longer period is
also necessary to clarify and discern in detail the importance of neonatal HG and other perinatal factors
in neurodevelopmental damage.
personality disorders and death. The longest the HG lasts and the greatest the glucose nadir the consequences are more pronounced.
Comorbidities are rather important in development of neurological damage. Hypoxemia and ischemia can
cause permanent brain damage. Small for gestational age (SGA), large for gestational age (LGA), intrauterine growth restriction, gestational age bellow the 37th week, low Apgar score, sepsis, children whose
mothers have toxemia, diabetes or chorioamnionitis are all newborns with increased HG risk.
Comparing 34 patients with NH and 34 children without NH with similar GA, BW, BL, the Apgar score,
we found statistically significant differences in motor and mental development using the Griffith scale.
Children with neonatal HG fared significantly worse than those without neonatal HG. Therefore, CBG
measurements and early recognition of neonatal HG is of significant importance in preventing motor and
mental damage in children. A larger and well-balanced cohort of patients followed for a longer period is
also necessary to clarify and discern in detail the importance of neonatal HG and other perinatal factors
in neurodevelopmental damage.
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