Please use this identifier to cite or link to this item:
http://hdl.handle.net/20.500.12188/11543
DC Field | Value | Language |
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dc.contributor.author | M Krstevska-Konstantinova | en_US |
dc.contributor.author | M Kocova | en_US |
dc.contributor.author | C Charlier | en_US |
dc.contributor.author | J Bourguignon | en_US |
dc.date.accessioned | 2021-03-25T10:47:56Z | - |
dc.date.available | 2021-03-25T10:47:56Z | - |
dc.date.issued | 2007-04-01 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.12188/11543 | - |
dc.description.abstract | Premature sexual development (PSD) in girls describes the appearance of secondary sexual signs before the age of 8 years. Early puberty is diagnosed if pubertal signs appear between the age of 8 and 9 years. We found a positive association between the levels of organochloride pesticides (p,p'-DDE) in precocious puberty in girls adopted from developing countries and significantly higher levels than in native Belgian girls with the same condition.</jats:p><jats:p>We have compared the serum levels of eight p,p'- DDE in 56 Macedonian girls with PSD and a control group of 24 normal, age-matched girls, using a gas chromatographic analyzer coupled to a tandem mass spectrometer detector. Of the 56 girls with PSD, 42 had premature thelarche, five had early puberty, and nine had precocious puberty of idiopathic (<jats:italic>n</jats:italic> = 8) or organic (<jats:italic>n</jats:italic> = 1) origin. We found traces of p,p'- DDE in nine girls (16%) and negative results in 41 (73%), while the remaining six (10%) had a mean level of 1.17 ± 0.7 μg/L. In the control group, traces were found in one girl (4%) and negative results in 18 (75%), while the remaining five (20%) had a mean level of 1.18 ± 0.6 μg/L. We found elevated levels of lindane in the girls with PSD (mean value 1.2 ± 0.8) and significantly higher levels in the control group (1.4 ± 0.8) (<0.05). We concluded that Macedonian girls with PSD do not have higher levels of p,p'-DDE in their serum than the normal controls. However, the elevated levels of lindane in this population should be further investigated. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Walter de Gruyter GmbH | en_US |
dc.relation.ispartof | Balkan Journal of Medical Genetics | en_US |
dc.title | Organochloride Pesticides in Macedonian Girls With Premature Sexual Development | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.2478/v10034-007-0008-3 | - |
dc.identifier.url | https://content.sciendo.com/view/journals/bjmg/10/1/article-p43.xml | - |
dc.identifier.url | https://content.sciendo.com/downloadpdf/journals/bjmg/10/1/article-p43.xml | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 1 | - |
dc.identifier.fpage | 43 | - |
dc.identifier.lpage | 48 | - |
item.grantfulltext | none | - |
item.fulltext | No Fulltext | - |
crisitem.author.dept | Faculty of Medicine | - |
crisitem.author.dept | Faculty of Medicine | - |
Appears in Collections: | Faculty of Medicine: Journal Articles |
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