EXTREMELY LOCALLY ADVANCED OVARIAN MALIGNANT MIXED MULLERIAN TUMOR IN 37-YEARS-OLD FEMALE
Journal
Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)
Date Issued
2017-03-01
Author(s)
Gelevski Radomir
Karadzov Zoran
Selmani Redzep
Jovanovska Manevska Vesna
DOI
10.1515/prilozi-2017-0010
Abstract
Ovarian carcinosarcomas, rare variant of ovarian carcinoma, composed of both carcinomatous and mesenchymal
components, solid and/or cystic, fleshy and hemorrhagic, frequently spreading beyond the ovary, are treated
with surgery and adjuvant chemotherapy according to the treatment principles of ovarian carcinomas due to
the small number of reported cases and lack of randomized studies. We report a case of a 37-year-old woman
with clinical signs of extremely locally advanced tumor of ovarian origin, infiltrating the lower left quadrant of
the abdominal wall with necrosis of the covering skin. Prior biopsy of the left ovary and omentum confirmed
poorly differentiated serous adenocarcinoma. Bulky tumor the size of a child’s head, originating from the left
ovary and infiltrating into the lower left quadrant abdominal wall was debulked with wide excision of the
abdominal wall and creation of wide defect of the lower left part of abdominal wall covered with Dexon mesh.
After the recovery, the medial part of the defect with exposed mesh was closed with pedicled tensor fasciae
latae fasciomyocutaneous flap, while the lateral part of the defect was covered with split thickness skin graft.
Optimal surgical cytoreduction and adjuvant chemotherapy in case of extremely locally advanced ovarian
malignant Müllerian tumor provide satisfactory recurrence-free survival period.
components, solid and/or cystic, fleshy and hemorrhagic, frequently spreading beyond the ovary, are treated
with surgery and adjuvant chemotherapy according to the treatment principles of ovarian carcinomas due to
the small number of reported cases and lack of randomized studies. We report a case of a 37-year-old woman
with clinical signs of extremely locally advanced tumor of ovarian origin, infiltrating the lower left quadrant of
the abdominal wall with necrosis of the covering skin. Prior biopsy of the left ovary and omentum confirmed
poorly differentiated serous adenocarcinoma. Bulky tumor the size of a child’s head, originating from the left
ovary and infiltrating into the lower left quadrant abdominal wall was debulked with wide excision of the
abdominal wall and creation of wide defect of the lower left part of abdominal wall covered with Dexon mesh.
After the recovery, the medial part of the defect with exposed mesh was closed with pedicled tensor fasciae
latae fasciomyocutaneous flap, while the lateral part of the defect was covered with split thickness skin graft.
Optimal surgical cytoreduction and adjuvant chemotherapy in case of extremely locally advanced ovarian
malignant Müllerian tumor provide satisfactory recurrence-free survival period.
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