Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies

Pörksen, Sven; Laborie, Lene Bjerke; Nielsen, Lotte; Louise Max Andersen, Marie; Sandal, Tone; de Wet, Heidi; Schwarcz, Erik; Aman, Jan; Swift, Peter; Kocova, Mirjana; Schönle, Eugen J; de Beaufort, Carine; Hougaard, Philip; Ashcroft, Frances; Molven, Anders; Knip, Mikael; Mortensen, Henrik B; Hansen, Lars; Njølstad, Pål R

doi:10.1186/1472-6823-10-16

Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies

Journal

BMC Endocrine Disorders

Date Issued

2010-09-23

Author(s)

Pörksen, Sven

Laborie, Lene Bjerke

Nielsen, Lotte

Louise Max Andersen, Marie

Sandal, Tone

de Wet, Heidi

Schwarcz, Erik

Aman, Jan

Swift, Peter

Schönle, Eugen J

de Beaufort, Carine

Hougaard, Philip

Ashcroft, Frances

Molven, Anders

Knip, Mikael

Mortensen, Henrik B

Hansen, Lars

Njølstad, Pål R

DOI

10.1186/1472-6823-10-16

Abstract

To investigate disease progression the first 12 months after diagnosis in children with type 1 diabetes negative (AAB negative) for pancreatic autoantibodies [islet cell autoantibodies(ICA), glutamic acid decarboxylase antibodies (GADA) and insulinoma-associated antigen-2 antibodies (IA-2A)]. Furthermore the study aimed at determining whether mutations in KCNJ11, ABCC8, HNF1A, HNF4A or INS are common in AAB negative diabetes.