EVALUATION THE VALUE OF INFLAMMATORY BIOCHEMISTRY MARKERS AT THE NEWBORNS WITH SEPSIS IN THE INTENSIVE CARE UNIT

Abstract

Objective: The aim of this study was to evaluate the predictive values of procalcitonin (PCT) as a early diagnostic and prognostic biochemical marker for sepsis in newborns in correlation withC reactive protein (CRP) and white blood cells count(WBC). Methods: In a prospective study, 110 newborns with two or three clinical signs of sepsis who admitted at the Intensive Care Unit (ICU) at the PHI University Clinic of Pediatric Diseases-Skopje were included . Diagnosis of sepsis in newborns diagnosed according to standard protocols for diagnosis of disease. Sample for blood culture, PCT CRP and WBC obtained by peripheral venous puncturewere taken the first at the admission, before initiation of antibiotic therapy in newborns suspected of sepsis, the second on 3-5 days and the third 6-14 days. Results: 110 newborns were recruited. At first 24 hours of the admission , PCT have a higher discriminative ability than the WBC in distinguishing a bacterial infection from another inflammatory process the early infection diagnosis, and also found to have been more reliable than that of the CRP. The highest average values of PCT (40.37±53.79) were measured during admission with a subsequent sharp jump. The highest average values of CRP were measured (42.17±61.84) after the second during with a subsequent sharp jump. In the three measurements they had an average value WBC (16.83±8.35, 16.71±9.64. 16.31±11.72).Conclusion: The values of procalcitonin (PCT) is a important clinical significance in diagnosis treatment and predicting the prognosis of newborns with sepsis.