Acpa Antibody In Diagnosis Of Early Undiferentiated Seronegative Arthropaty

Abstract

Objectives: To compare the values and acuracy of the test peptides (Anti-CCP /ACPA) antibodies, Rheumatoid factor (RF), C-Reactive Protein (CRP) in early diagnosis of untreated seronegative arthropaty. Material and Methods: Using the ELISA method of DIA-STATTM Anti CCP (Axis–Shield Diagnostics), sera of 70 participants were examined (35 untreated patients with PsA and 35 persons from the healthy control group). RF and CRP were determined with the agglutination test (Lateks test) in the same participants. In the same time we determined the sensitivity, specificity, predictive value for positive and negative test and accuracy. Results: From 35 pts with seronegative arthropaty, 1 patient showed presence of Anti-CCP antibodies (sensitivity test 2.86%), while RF was present in 0 pts (sensitivity test 0%). In the healthy control group positive values for RF, CRP and Erythroid Sedimentation Rate (ESR) were detected in 1 participant. Conclusion: ACPA antibodies have low sensitivity, but high specificity in seronegative arthropaty.