CERTAIN ASPECTS OF ACPA ANTIBODIES AND REACTANTS OF ACUTE PHASE IN PATIENTS WITH RHEUMATOID ARTHRITIS
Journal
Македонски медицински преглед = Macedonian Medical Review
Date Issued
2020
Author(s)
Abstract
Introduction. Radiographic evaluation remains the most
important tool for evaluation of the structural damage
of joints and skeleton. Progression of the radiographic
damage of hand and feet joints is a significant and objective variable for evaluation of disease activity as well
as for measurement of treatment outcome
Aim. To compare the values of rheumatoid factor (RF),
C-reactive protein (CRP) and DAS28 index in the early
diagnosis of untreated rheumatoid arthritis (RA). To evaluate the RA activity with radiographic evaluation of hand
joints in patients with early RA treated with Methotrexate.
Methods. Using ELISA method DIA-STATTM Anti CCP
(Axis-Shield Diagnostics), we tested sera of 70 participants (35 untreated RA, 35 control group). RF was determined with the agglutination test (Latex RF test) in the
participants. Patients were treated with Methotrexate at
an average dose of 10 mg once weekly. For clinical evaluation of disease activity in every patient radiographic
index (RI), sedimentation, CRP and RF at certain time
intervals (time 0, after 6, 9 and 12 months) were analyzed.
Results. RA was evaluated by follow-up of the dynamics of the changes of mean values of RI score, mean
values of sedimentation, CRP and RF. RI showed an increased radiographic progression of hand joint damage at
time intervals between 0 and 9 months (p=0.0167) and
between 0 and 12 months (p=0.0089). Statistical analysis
showed statistically significant differences among mean
values of ESR at four time intervals (p=0.00002). Also,
statistically significant differences were shown in the
mean values of CRP at four time intervals (p=0.0428)
(standard deviations showed great variations). There were no statistically significant differences among mean
values of RF at four time intervals (p=0.573). At time
0 in 3 (10%) patients (pts) RI progression was seen, after
6 months in 13 (39%), while after 9 and 12 months RI
progression was seen in an equal number of patients15(50%). In most patients increased values of RF and
CRP were registered.
Conclusion. Despite the Methotrexate therapy, progression of the radiographic damage continues, especially
in patients with increased values of sedimentation, CRP
and RF and persistence of previous hand joints erosions,
as predictors of the aggressive course of disease. They
enable selection of the high-risk groups for aggressive
course of disease and indicate the need for early and
aggressive treatment.
important tool for evaluation of the structural damage
of joints and skeleton. Progression of the radiographic
damage of hand and feet joints is a significant and objective variable for evaluation of disease activity as well
as for measurement of treatment outcome
Aim. To compare the values of rheumatoid factor (RF),
C-reactive protein (CRP) and DAS28 index in the early
diagnosis of untreated rheumatoid arthritis (RA). To evaluate the RA activity with radiographic evaluation of hand
joints in patients with early RA treated with Methotrexate.
Methods. Using ELISA method DIA-STATTM Anti CCP
(Axis-Shield Diagnostics), we tested sera of 70 participants (35 untreated RA, 35 control group). RF was determined with the agglutination test (Latex RF test) in the
participants. Patients were treated with Methotrexate at
an average dose of 10 mg once weekly. For clinical evaluation of disease activity in every patient radiographic
index (RI), sedimentation, CRP and RF at certain time
intervals (time 0, after 6, 9 and 12 months) were analyzed.
Results. RA was evaluated by follow-up of the dynamics of the changes of mean values of RI score, mean
values of sedimentation, CRP and RF. RI showed an increased radiographic progression of hand joint damage at
time intervals between 0 and 9 months (p=0.0167) and
between 0 and 12 months (p=0.0089). Statistical analysis
showed statistically significant differences among mean
values of ESR at four time intervals (p=0.00002). Also,
statistically significant differences were shown in the
mean values of CRP at four time intervals (p=0.0428)
(standard deviations showed great variations). There were no statistically significant differences among mean
values of RF at four time intervals (p=0.573). At time
0 in 3 (10%) patients (pts) RI progression was seen, after
6 months in 13 (39%), while after 9 and 12 months RI
progression was seen in an equal number of patients15(50%). In most patients increased values of RF and
CRP were registered.
Conclusion. Despite the Methotrexate therapy, progression of the radiographic damage continues, especially
in patients with increased values of sedimentation, CRP
and RF and persistence of previous hand joints erosions,
as predictors of the aggressive course of disease. They
enable selection of the high-risk groups for aggressive
course of disease and indicate the need for early and
aggressive treatment.
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