DETECTION OF JAK2 V617F MUTATION IN A PATIENT WITH C-KIT POSITIVE GASTROINTESTINAL STROMAL TUMOR: CASE REPORT

Trajkova, Sanja; Krstevska Balkanov, Svetlana; Pivkova Veljanovska, Aleksandra; Lichoska Josifovikj, Fana; Popova Labachevska, Marija; Ridova, Nevenka; Stojanovska Jakimovska, Simona; Cvetanovski, Milche; Kochoski, Bozhidar; Paunovska, Andrea; Stojanovski, Martin; Purde, Merve; Panovska Stavridis, Irina

doi:10.55302/jms2581193t

DETECTION OF JAK2 V617F MUTATION IN A PATIENT WITH C-KIT POSITIVE GASTROINTESTINAL STROMAL TUMOR: CASE REPORT

Journal

Journal of Morphological Sciences

Date Issued

2025-05-02

Author(s)

Popova Labachevska, Marija

Ridova, Nevenka

Stojanovska Jakimovska, Simona

Cvetanovski, Milche

Kochoski, Bozhidar

Paunovska, Andrea

Stojanovski, Martin

Purde, Merve

DOI

10.55302/jms2581193t

Abstract

C-Kit is receptor tyrosine kinase which is involved in various signaling pathways and has been recognized in pathogenesis of several types of cancers including gastrointestinal stromal tumor (GIST). More than 50 years, scientist have been studied GIST and made advances in treatment based on c-Kit inhibition. One of the signaling pathway involving activation via c-Kit is the JAK/STAT pathway located on hematopoietic cells resulting activation of transcription of a variety of genes. Here, we provide a case report of patient with two malignancy c-Kit positive GIST and Essential Thrombocytemia (ET) positive for JAK2 V617F mutation.

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