Effect of simvastatin in apolipoprotein E deficient mice with surgically induced chronic renal failure

Ivanovski, Ognen; Szumilak, Dorota; Nguyen-Khoa, Thao; Nikolov, Igor G; Joki, Nobuhiko; Mothu, Nadya; Maizel, Julien; Westenfeld, Ralf; Ketteler, Marcus; Lacour, Bernard; Drüeke, Tilman B; Massy, Ziad A

doi:10.1016/j.juro.2007.11.042

Effect of simvastatin in apolipoprotein E deficient mice with surgically induced chronic renal failure

Journal

The Journal of urology

Date Issued

2008-04

Author(s)

Szumilak, Dorota

Nguyen-Khoa, Thao

Joki, Nobuhiko

Mothu, Nadya

Maizel, Julien

Westenfeld, Ralf

Ketteler, Marcus

Lacour, Bernard

Drüeke, Tilman B

Massy, Ziad A

DOI

10.1016/j.juro.2007.11.042

Abstract

Patients with a surgically reduced renal mass are at increased risk for progressive renal failure, which often requires renal replacement therapy or kidney transplantation. We investigated the effects of simvastatin supplementation on uremia enhanced atherosclerosis and vascular calcification in apoE(-/-) (apolipoprotein E deficient) mice (Charles Rivers Laboratories, Wilmington, Massachusetts) with or without superimposed chronic kidney disease.