Eosinophilic ulcer of the oral mucosa: report of a case with multiple synchronous lesions

Damevska, Katerina; Gocev, Gorgi; Nikolovska, Suzana

doi:10.1097/DAD.0b013e31829ae478

Eosinophilic ulcer of the oral mucosa: report of a case with multiple synchronous lesions

Journal

The American Journal of Dermatopathology

Date Issued

2014-07

Author(s)

Gocev, Gorgi

DOI

10.1097/DAD.0b013e31829ae478

Abstract

Eosinophilic ulcer of the oral mucosa is considered to be a benign, reactive, and self-limiting lesion, with unclear pathogenesis, manifesting as a rapidly developing solitary ulcer. We report the case of a 52-year-old man who presented with 4 synchronous ulcerations of the tongue. Histopathological examination showed polymorphic inflammatory infiltrate, rich in eosinophils, involving the superficial mucosa and the deeper muscle layer. Immunohistochemical analysis revealed single CD30 cells scattered within an inflammatory infiltrate. All the lesions began to regress spontaneously within 1 week after biopsy. A 4-year follow-up showed no recurrence.