Drug Interactions
Journal
Macedonian Journal of Anaesthesia
Date Issued
2024
Author(s)
Abstract
Drug interactions can be described as the pharmacological influence of one drug on another
drug, when administered in combination. Drug interaction can cause an increased or decreased
effect of the drug, but it can also lead to a toxic effect. In daily practice in operating rooms and
intensive care units, anesthesiologists routinely combine drugs. Interactions are usually divided
according to the mechanism of occurrence and the most frequent are pharmacokinetic and
pharmacodynamic. In pharmacokinetic interactions, the interactions are at the level of
absorption, distribution, metabolism, or elimination processes. Such interactions are predictable,
but their extent cannot be predicted. Pharmacodynamic interactions refer to antagonistic or
synergistic action between drugs. It remains a challenge to teach clinicians how to combine these
drugs in order to achieve and maintain optimal anesthetic and vital conditions, while minimizing
side effects. A good understanding and knowledge of drug interactions can improve the ability to
titrate multiple drugs more effectively.
drug, when administered in combination. Drug interaction can cause an increased or decreased
effect of the drug, but it can also lead to a toxic effect. In daily practice in operating rooms and
intensive care units, anesthesiologists routinely combine drugs. Interactions are usually divided
according to the mechanism of occurrence and the most frequent are pharmacokinetic and
pharmacodynamic. In pharmacokinetic interactions, the interactions are at the level of
absorption, distribution, metabolism, or elimination processes. Such interactions are predictable,
but their extent cannot be predicted. Pharmacodynamic interactions refer to antagonistic or
synergistic action between drugs. It remains a challenge to teach clinicians how to combine these
drugs in order to achieve and maintain optimal anesthetic and vital conditions, while minimizing
side effects. A good understanding and knowledge of drug interactions can improve the ability to
titrate multiple drugs more effectively.
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