MARIJUANA-INDUCED ACUTE CORONARY SYNDROME IN A YOUNG PATIENT
Journal
Macedonian Journal of Anaesthesia
Date Issued
2023
Author(s)
Jovanoski, Mario
Andov, Mishel
Abstract
Introduction: Acute coronary syndrome (ACS) is generally a natural consequence of the
progression of coronary atherosclerosis. But in minority of cases, it might be developed due to
non-atherosclerotic reasons including recreational marijuana use. Possible pathophysiological
mechanisms include inflammation, procoagulant state and vasoconstriction (vasospasm) of
the coronary arteries. Marijuana adverse effects on cardiovascular system are various and well
documented.
Case report: We present a 29-years old male who was referred to our Clinic due to chest pain
and morphologic ECG changes. The patient has been previously hospitalized in local hospital
due to hematochezia. Because of the chest pain, ECG was performed, and blood sample was
taken there to determine the troponin level (hs-Tn I). ST-segment elevation and high level of hsTn I were indication for urgent transfer of the patient to our clinic. After admission, the patient
underwent coronary angiography and PCI. Thoroughly taken history revealed that the patient
was occasionally smoking marijuana in recreational purposes. He was a cigarette smoker, but he
had no additional known risk factors for CAD.
Conclusion: Recreational marijuana use may be a trigger factor for an acute coronary syndrome.
We should always think and suspect marijuana and other recreational drugs as a potential risk
factor for adverse cardiovascular events in young patients.
progression of coronary atherosclerosis. But in minority of cases, it might be developed due to
non-atherosclerotic reasons including recreational marijuana use. Possible pathophysiological
mechanisms include inflammation, procoagulant state and vasoconstriction (vasospasm) of
the coronary arteries. Marijuana adverse effects on cardiovascular system are various and well
documented.
Case report: We present a 29-years old male who was referred to our Clinic due to chest pain
and morphologic ECG changes. The patient has been previously hospitalized in local hospital
due to hematochezia. Because of the chest pain, ECG was performed, and blood sample was
taken there to determine the troponin level (hs-Tn I). ST-segment elevation and high level of hsTn I were indication for urgent transfer of the patient to our clinic. After admission, the patient
underwent coronary angiography and PCI. Thoroughly taken history revealed that the patient
was occasionally smoking marijuana in recreational purposes. He was a cigarette smoker, but he
had no additional known risk factors for CAD.
Conclusion: Recreational marijuana use may be a trigger factor for an acute coronary syndrome.
We should always think and suspect marijuana and other recreational drugs as a potential risk
factor for adverse cardiovascular events in young patients.
Subjects
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