Low Pregnancy Associated Plasma Protein A as a Predictive Tool for Pregnancy Outcome

Journal
Biomedical Journal of Scientific & Technical Research (BJSTR)
Date Issued
2023-08-04
Author(s)
Aliu, Nurije
Dimitrovska, Jasmina
Todorovska, Irena
DOI
10.26717/BJSTR.2023.52.008191
Abstract
Objective: The objective of this study is to identify the predictive value of pregnancy-associated plasma protein A using univariate and multivariate regression analysis in identification of patients with low values (less than 0.4 MoM) in combined first-trimester screening for predicting disadvantaged perinatal outcome after exclusion of aneuploidy.
Methods: A study was conducted at the University clinic for gynecology and obstetrics in Skopje, over a one-year period (2018 y). Those with PAPP-A values (<0.4 MoM) of 64 and a control group of 50 patients with values ≥0.4 MoM. The concentration of PAPP-A was measured from peripheral blood and determined by Immulite 2000 HPi Systems Analyzer.
Results: Univariate and multivariate logistic regression analyses were used to assess the predictive role of PAPP-A. The unadjusted OR for PAPP-A for preterm delivery was 0.225, for antepartum complications was 0.138, for intrauterine growth restriction of 0.049. In the adjusted logistic regression analysis, PAPP-A was not found to be a significant predictor of respiratory distress syndrome, newborn infections, NICU stay and pH≤7.2. The adjusted OR for antepartum complications was 0.131, for intrauterine growth restriction was 0.053.
Conclusion: It can be concluded that PAPP-A levels in the first trimester are associated with intrauterine growth restriction and antepartum complications. The study suggests that caution is needed in pregnancies with PAPP-A values below 0.3 MoM.
Subjects

Perinatal Outcome

PAPP-A

First Trimester

Intrauterine Growth R...

Preterm Birth

Predictive

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Low Pregnancy Associated Plasma Protein A as a Predictive Tool for Pregnancy Outcome.pdf

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PAPP A below 0.4 MoM could be used as a additional predictive tool for SGA and expec tance of above mention complication before delivery. Assuming these results and results from the literature, it could be contributed for decrease perinatal morbidity and mortality.
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