Cases of Guillain-Barre Sundrome associated with COVID-19
Journal
Medicus
Date Issued
2022
Author(s)
Dalipi, Teuta
Stojkovska, Frosina
Mitrevska Velkov, Jasmina
Babunovska, Marija
DOI
http://www.medalb.com/revista/medicus-prill-2022.pdf
Abstract
A novel member of human RNA coronavirus, which is an enveloped betacoronavirus, has been termed severe
acute respiratory syndrome coronavirus-2 (SARS COV-2). The illness caused by SARS COV-2 is referred to as the
coronavirus disease 2019 (COVID-19). It is a highly contagious disease that has resulted in a global pandemic.
The clinical spectrum of COVID-19 ranges from asymptomatic illness to acute respiratory distress syndrome,
septic shock, multi-organ dysfunction, and death. The most common symptoms include fever, fatigue, dry cough,
dyspnea, and diarrhea. Neurological manifestations have also been reported. However, the data on the association
of Guillain-Barré syndrome (GBS) with COVID-19 are scarce. We report two case of a COVID-19-positive patients
who presents clinical features of GBS.
In both cases clinical examination showed generalized weakness mostly in lower extremitis and hyporeflexia.
The cerebrospinal fluid (CSF) analysis showed albuminocytological dissociation. The neurological condition was
different in both patients they both recived kortikosteroids in first case it has good results but in second cases
Intravenous immunoglobulin (IVIG) was administered. A thoracolumbar spine magnetic resonance imaging was
obtained to rule out other causes, which was normal. COVID-19 is believed to cause a dysregulated immune
system, which likely plays an important role in the neuropathogenesis of GBS.
acute respiratory syndrome coronavirus-2 (SARS COV-2). The illness caused by SARS COV-2 is referred to as the
coronavirus disease 2019 (COVID-19). It is a highly contagious disease that has resulted in a global pandemic.
The clinical spectrum of COVID-19 ranges from asymptomatic illness to acute respiratory distress syndrome,
septic shock, multi-organ dysfunction, and death. The most common symptoms include fever, fatigue, dry cough,
dyspnea, and diarrhea. Neurological manifestations have also been reported. However, the data on the association
of Guillain-Barré syndrome (GBS) with COVID-19 are scarce. We report two case of a COVID-19-positive patients
who presents clinical features of GBS.
In both cases clinical examination showed generalized weakness mostly in lower extremitis and hyporeflexia.
The cerebrospinal fluid (CSF) analysis showed albuminocytological dissociation. The neurological condition was
different in both patients they both recived kortikosteroids in first case it has good results but in second cases
Intravenous immunoglobulin (IVIG) was administered. A thoracolumbar spine magnetic resonance imaging was
obtained to rule out other causes, which was normal. COVID-19 is believed to cause a dysregulated immune
system, which likely plays an important role in the neuropathogenesis of GBS.
Subjects