Immunotactoid glomerulopathy: A rare glomerular disease case study
Journal
Indian Journal of Nephrology
Date Issued
2022
Author(s)
DOI
10.4103/ijn.ijn_107_22
Abstract
Immunotactoid glomerulopathy (ITG) is a rare glomerular disease with variable responsiveness to
the immunosuppressive therapy and with uncertain prognosis. ITG was diagnosed in two patients
with type 2 diabetes mellitus with nephrotic syndrome and chronic kidney disease. The absence of
diabetic retinopathy in the first case and the recent onset of diabetes in the second case accompanied
with sudden increase in the 24‑hour proteinuria and rapid decline in kidney function, prompted us to
perform kidney biopsy. The electron microscopy set the diagnosis of ITG in both cases. There is no
consensus for the treatment of ITG. The first patient was treated with combination of steroids and
mycophenolate mofetil with reduction of the 24‑hour proteinuria, but with persistence of the chronic
kidney disease. The second patient received high doses of steroids with continuous deterioration of
kidney function with the need of hemodialysis treatment.
the immunosuppressive therapy and with uncertain prognosis. ITG was diagnosed in two patients
with type 2 diabetes mellitus with nephrotic syndrome and chronic kidney disease. The absence of
diabetic retinopathy in the first case and the recent onset of diabetes in the second case accompanied
with sudden increase in the 24‑hour proteinuria and rapid decline in kidney function, prompted us to
perform kidney biopsy. The electron microscopy set the diagnosis of ITG in both cases. There is no
consensus for the treatment of ITG. The first patient was treated with combination of steroids and
mycophenolate mofetil with reduction of the 24‑hour proteinuria, but with persistence of the chronic
kidney disease. The second patient received high doses of steroids with continuous deterioration of
kidney function with the need of hemodialysis treatment.