Overall survival in myelodysplastic syndromes: a cohort study
Journal
Journal of Research in Humanities and Social Science
Date Issued
2014-12-25
Author(s)
Svetlana Krstevska
Abstract
Factors like age, gender, FAB subtypes, cytopenias, proportion of bone marrow (BM) blasts,
comorbidities, transfusion dependence, albumins, lactate dehydrogenase (LDH), karyotype abnormalities and
molecular biomarkers can refine the prediction of prognosis in MDS. The aim of this study was to evaluate
factors that influence overall survival (OS) in MDS.
We conducted retrospective cohort study of 184patients (98 male, 86 female) with MDS who presented
to the University Clinic of Hematology, Skopje, Macedonia, from January 2011 to October 2014. The
differences in OS between male and female were not significant (p = .08368). The mean age at diagnosis was
66,5 years. Differences in OS among FAB subtypes were significant (p = .00117). OS inversely correlated with
BM blast percentage (p = .00054). Hemoglobin, platelets and absolute neutrophil count (ANC) did not influence
OS - p=0.107161, (p= .79288) and (p= .94860), respectfully. Ferritin (p = .63575), LDH and transfusion (p=
.48247) did not influence OS. Albumins and comorbidities influenced OS (p= .01137 and p= .00184,
respectfully). We can conclude that FAB subtypes, BM blast percentage, albumins and comorbidities had an
influence on OS, while age, gender, hemoglobin, platelet count, ANC, transfusion dependence and LDH had no
impact on OS.
comorbidities, transfusion dependence, albumins, lactate dehydrogenase (LDH), karyotype abnormalities and
molecular biomarkers can refine the prediction of prognosis in MDS. The aim of this study was to evaluate
factors that influence overall survival (OS) in MDS.
We conducted retrospective cohort study of 184patients (98 male, 86 female) with MDS who presented
to the University Clinic of Hematology, Skopje, Macedonia, from January 2011 to October 2014. The
differences in OS between male and female were not significant (p = .08368). The mean age at diagnosis was
66,5 years. Differences in OS among FAB subtypes were significant (p = .00117). OS inversely correlated with
BM blast percentage (p = .00054). Hemoglobin, platelets and absolute neutrophil count (ANC) did not influence
OS - p=0.107161, (p= .79288) and (p= .94860), respectfully. Ferritin (p = .63575), LDH and transfusion (p=
.48247) did not influence OS. Albumins and comorbidities influenced OS (p= .01137 and p= .00184,
respectfully). We can conclude that FAB subtypes, BM blast percentage, albumins and comorbidities had an
influence on OS, while age, gender, hemoglobin, platelet count, ANC, transfusion dependence and LDH had no
impact on OS.
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