EARLY DIAGNOSTIC OF SEPSIS IN NEWBORNS WITH RESPIRATORY DISTRESS SYNDROME
Journal
Medicus
Date Issued
2020
Author(s)
Elizabeta Shuperliska
Avdi Murtezani
Abstract
Objective: Early diagnosis of sepsis in newborns with RDS is essential for life-threatening condition, for reducing
severe sepsis and septic shock in the Intensive care Unit at the University Children’s Hospital in Skopje.Methods: In
this prospective study, we included 100 (M:F=59:41) newborns with Respiratory distress syndrome (RDS) suspected
for sepsis admitted in the Intensive Care Unit in period of December 2019 till 31 May 2020 y. Procalcitonin levels
were measured by using a immunoassay system Vidas based on the ELFA principles. Results: The newborns with
RDS suspected for sepsis have been divided into two groups The first group included 50 newborns with RDS and
positive blood culture and the second group included 50 newborns with RDS and negative blood culture. Тhe
average gestational age of the newborn with RDS and positive blood culture was 36,01± 3,1 weeks and the newborn
with RDS and negative blood culture 36,26± 3,2 weeks. Preterm newborns in both groups dominated (64,2% and
58,2%). Тhe average birth weight of the newborn with RDS and positive blood culture was 2490,5 ±791,6 grams,
and the newborn with RDS and negative blood culture was 2690,2±788,5grams. There is statistically significant
difference in average PCT between the two groups overtime (p<0.05). There is statistically significant difference
in average PCT between the two groups overtime procedure (MV , BCPAP, OXYGEN MASK) (p<0.05).Conclusions:
PCT is promising sepsis markers in newborns with RDS, capable of complementing clinical signs and routine lab
parameters suggestive of severe infection at the time of ICU admission
severe sepsis and septic shock in the Intensive care Unit at the University Children’s Hospital in Skopje.Methods: In
this prospective study, we included 100 (M:F=59:41) newborns with Respiratory distress syndrome (RDS) suspected
for sepsis admitted in the Intensive Care Unit in period of December 2019 till 31 May 2020 y. Procalcitonin levels
were measured by using a immunoassay system Vidas based on the ELFA principles. Results: The newborns with
RDS suspected for sepsis have been divided into two groups The first group included 50 newborns with RDS and
positive blood culture and the second group included 50 newborns with RDS and negative blood culture. Тhe
average gestational age of the newborn with RDS and positive blood culture was 36,01± 3,1 weeks and the newborn
with RDS and negative blood culture 36,26± 3,2 weeks. Preterm newborns in both groups dominated (64,2% and
58,2%). Тhe average birth weight of the newborn with RDS and positive blood culture was 2490,5 ±791,6 grams,
and the newborn with RDS and negative blood culture was 2690,2±788,5grams. There is statistically significant
difference in average PCT between the two groups overtime (p<0.05). There is statistically significant difference
in average PCT between the two groups overtime procedure (MV , BCPAP, OXYGEN MASK) (p<0.05).Conclusions:
PCT is promising sepsis markers in newborns with RDS, capable of complementing clinical signs and routine lab
parameters suggestive of severe infection at the time of ICU admission
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