Distribution of HPV types among patients with positive histological findings for cervical precancerous lesions and invasive cancer of the uterine cervix
Journal
Македонски медицински преглед = Macedonian Medical Review
Date Issued
2018
Author(s)
Dzikova, Elena
Dimitrov, Gligor
Kjajova, Ivana
Abstract
Introduction. The aim of this study was to provide
basic data on the prevalence of different HPV types
among the female population in R. Macedonia with
histologically proven cervical intraepithelial neoplasia
or invasive cervical cancer, in order to better plan the
vaccination program and screening for cervical cancer.
Mеthods. This study retrospectively statistically (using
Statistica SPSS for Windows) analyzed histological
findings positive for cervical intraepithelial neoplasia
or invasive cervical cancer and positive HPV genoty-
ping results of564 patients who came to the University
Clinic for Gynecology and Obstetrics due to an abnor-
mal Pap smear test during the last year (2017).
Results. HPV isolation showed the presence of human
papillomavirus in78% of the total of 564 subjects. The
prevalence of HPV in LSIL, HSIL, invasive squamo-
cellular carcinoma of the uterine cervix and adeno-
carcinoma of the uterine cervix was 69.2%, 87.2%,
97.6% and 71.4%, respectively. HR HPV types were
isolated in 75%of LSIL and 96% of HSIL. Predo-
minantly isolated were HPV types 16, 18, 35, 31, 33, 58,
6, 11 and 40. HPV type 16 wasthe most commonisolated
genotype among all patients with 48.4%, 30.1% and
19.6% in HSIL, invasive carcinoma and LSIL, respect-
tively. HPV type 18 had the highest rate in patients
with invasive adenocarcinoma of the cervix (30.1%).
Conclusion. Human papillomavirus types 16, 18, 35,
31, 33, 58, 6, 11 and 40were the predominant high risk
types in patients with invasive cervical cancer and its
precursors in the Republic of Macedonia.
basic data on the prevalence of different HPV types
among the female population in R. Macedonia with
histologically proven cervical intraepithelial neoplasia
or invasive cervical cancer, in order to better plan the
vaccination program and screening for cervical cancer.
Mеthods. This study retrospectively statistically (using
Statistica SPSS for Windows) analyzed histological
findings positive for cervical intraepithelial neoplasia
or invasive cervical cancer and positive HPV genoty-
ping results of564 patients who came to the University
Clinic for Gynecology and Obstetrics due to an abnor-
mal Pap smear test during the last year (2017).
Results. HPV isolation showed the presence of human
papillomavirus in78% of the total of 564 subjects. The
prevalence of HPV in LSIL, HSIL, invasive squamo-
cellular carcinoma of the uterine cervix and adeno-
carcinoma of the uterine cervix was 69.2%, 87.2%,
97.6% and 71.4%, respectively. HR HPV types were
isolated in 75%of LSIL and 96% of HSIL. Predo-
minantly isolated were HPV types 16, 18, 35, 31, 33, 58,
6, 11 and 40. HPV type 16 wasthe most commonisolated
genotype among all patients with 48.4%, 30.1% and
19.6% in HSIL, invasive carcinoma and LSIL, respect-
tively. HPV type 18 had the highest rate in patients
with invasive adenocarcinoma of the cervix (30.1%).
Conclusion. Human papillomavirus types 16, 18, 35,
31, 33, 58, 6, 11 and 40were the predominant high risk
types in patients with invasive cervical cancer and its
precursors in the Republic of Macedonia.
Subjects