Case report for management of pregnancy and delivery in severe factor XII deficiency
Journal
Редки Болести и Лекарства Сираци
Date Issued
2023
Author(s)
Dejanova-Ilievska Violeta
Makarovska Bojadjieva Tatjana
Ristovska Elena
Todorovski Bojan
Abstract
Factor XII deficiency is rare bleeding disorder and theoretically
may carry either bleeding risk as a result of reduced coagulation
factors or thrombosis risk as a consequence of reduced fibrinolytic
activity. The incidence of factor XII deficiency is relatively low at 1
in 1,000,000 people.
The aim of reported case is to emphasise the importance
of multidisciplinary approach in the management of pregnancy and
delivery in the women with severe factor XII deficiency.
A woman with severe factor XII deficiency was successfully
treated during her two pregnancies and deliveries. All coagulation
tests were performed with standard Siemens reagents on the
coagulometer Dade Behring BCS XP. A test for platelet aggregation for
follow up of Aspirin treatment was performed on Siemens Innovance
PFA-200 with standard Siemens collagen/epinephrin test cartridge.
During her two pregnancies, the woman with severe factor XII
deficiency was regularly followed up in the Center for haemophilia in
the Institute for Transfusion Medicine. According to coagulation tests
in the first pregnancy she was treated with low molecular weight
heparin in the postpartum period, but in the second pregnancy it
was necessary to be treated in the first and third trimester, as well
as in the postpartum period. Bleeding prevention due to delivery was
performed with tranexamic acid. Two pregnancies were successfully
finished with vaginal delivery without any bleeding or thrombotic
complications.
Regular follow up during pregnancy is necessary for women
with bleeding disorders in Comprehensive Haemophilia Treatment
Centre. Multidisciplinary approach is crucial for successful bleeding
disorders care
may carry either bleeding risk as a result of reduced coagulation
factors or thrombosis risk as a consequence of reduced fibrinolytic
activity. The incidence of factor XII deficiency is relatively low at 1
in 1,000,000 people.
The aim of reported case is to emphasise the importance
of multidisciplinary approach in the management of pregnancy and
delivery in the women with severe factor XII deficiency.
A woman with severe factor XII deficiency was successfully
treated during her two pregnancies and deliveries. All coagulation
tests were performed with standard Siemens reagents on the
coagulometer Dade Behring BCS XP. A test for platelet aggregation for
follow up of Aspirin treatment was performed on Siemens Innovance
PFA-200 with standard Siemens collagen/epinephrin test cartridge.
During her two pregnancies, the woman with severe factor XII
deficiency was regularly followed up in the Center for haemophilia in
the Institute for Transfusion Medicine. According to coagulation tests
in the first pregnancy she was treated with low molecular weight
heparin in the postpartum period, but in the second pregnancy it
was necessary to be treated in the first and third trimester, as well
as in the postpartum period. Bleeding prevention due to delivery was
performed with tranexamic acid. Two pregnancies were successfully
finished with vaginal delivery without any bleeding or thrombotic
complications.
Regular follow up during pregnancy is necessary for women
with bleeding disorders in Comprehensive Haemophilia Treatment
Centre. Multidisciplinary approach is crucial for successful bleeding
disorders care
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