Multidisciplinary approach to management of hypofibrinogenemia in pregnancy: a case report
Journal
SCRIPTA MEDICA
Date Issued
2020-06-30
Author(s)
Elizabeta Todorovska
Tatjana Makarovska Bojadjieva
Saso Stojcevski
Saso Spasovski
Violeta Dejanova
Radica Grubovic
Florije Raka
Irena Todorovska
Sasa Jovcevski
Daniel Milkovski
DOI
10.5937/scriptamed51-26499
Abstract
Inherited fibrinogen disorders introduce risk for recurrent abortions, sub-chorionic
haematoma, placental abruption and postpartum haemorrhage. This is a case report
of a successful pregnancy outcome in a 37-year old woman with hypofibrinogenaemia. She was referred to a coagulation test in the first trimester because of history of
preeclampsia and HELLP syndrome in previous pregnancy. Hypofibrinogenaemia was
diagnosed with fibrinogen level of 0.7 g/L. During the pregnancy she was regularly
monitored for fibrinogen levels and multiple cryoprecipitate concentrates were given.
She delivered at 39th gestation week, with elective caesarean section under general
anaesthesia. There was one episode of postpartum haemorrhage treated with 2 units
of red blood cells, repeated infusions of cryoprecipitate to obtain the level of fibrinogen of 2 g/L. She was discharged on the 6th postpartum day in a good condition. In
these disorders levels of fibrinogen should be higher than 1 g/L during pregnancy or
2 g/L in case of caesarean section for successful prenatal and peripartal management.
haematoma, placental abruption and postpartum haemorrhage. This is a case report
of a successful pregnancy outcome in a 37-year old woman with hypofibrinogenaemia. She was referred to a coagulation test in the first trimester because of history of
preeclampsia and HELLP syndrome in previous pregnancy. Hypofibrinogenaemia was
diagnosed with fibrinogen level of 0.7 g/L. During the pregnancy she was regularly
monitored for fibrinogen levels and multiple cryoprecipitate concentrates were given.
She delivered at 39th gestation week, with elective caesarean section under general
anaesthesia. There was one episode of postpartum haemorrhage treated with 2 units
of red blood cells, repeated infusions of cryoprecipitate to obtain the level of fibrinogen of 2 g/L. She was discharged on the 6th postpartum day in a good condition. In
these disorders levels of fibrinogen should be higher than 1 g/L during pregnancy or
2 g/L in case of caesarean section for successful prenatal and peripartal management.
File(s)![Thumbnail Image]()
Loading...
Name
26499-Tekst rukopisa-146426-1-10-20200630.pdf
Description
Multidisciplinary Approach to Management of Hypofibrinogenemia in Pregnancy, a Case Report
Size
150.28 KB
Format
Adobe PDF
Checksum
(MD5):97182e0628b9833cdf8375299dbfe827